5-hydroxymethyl-2-furfural

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-hydroxymethyl-2-furfural
• 英文别名: 5HMF；5-(Hydroxymethyl)-2,3-dihydrofuran-2-carbaldehyde；5-(hydroxymethyl)-2,3-dihydrofuran-2-carbaldehyde
• 化学式: C₆H₈O₃
• 分子量: 128.128
• InChiKey: LKJISVNPHNVAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-hydroxymethyl-2-furfural 、 对氨基苯甲酸 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以100%的产率得到4-((5-(hydroxymethyl)furan-2-yl)methyleneamino)benzoic acid
  参考文献：
  名称：

  Synthesis, composition and use of novel therapeutic and cosmetic Schiff base products formed by reaction of a carbonyl containing moeity with a transimination nucleophilic catalyst and the use of transimination nucleophilic catalysts to increase the rate at which carbonyl containing therapeutic and cosmetic actives form Schiff base products with biological amines

  摘要：

  本发明涉及通过将转移胺亲核催化剂（分子或聚合物）与含羰基的治疗或化妆品基团反应而形成的新颖基团的合成、组成和使用。所得的席夫碱产物对生物胺的转移胺反应具有高度的反应性。催化剂和含羰基基团可以是分子或聚合物，并且通过适当选择所述催化剂可以调控席夫碱产物的化学和物理性质。本发明还涉及合成、组成和使用作为无阳光晒黑制剂中活性成分的新颖基团。本发明还涉及使用转移胺亲核催化剂来增加含羰基基团与生物胺反应的速率。本发明还涉及使用转移胺亲核催化剂来提高商业无阳光晒黑制剂的速率和功效。所述制剂的稳定性和功效的改进被披露。虽然本发明已根据其首选实施方式进行了描述，但技术领域的专业人士将认识到，本发明可以在附图权利要求的精神和范围内进行修改实施。因此，本发明不应仅限于上述描述的实施方式，而应进一步包括本文所提供的描述的精神和范围内的所有修改和等效物。

  公开号：

  US09365532B1

文献信息

• BIPHASIC SOLVENT CATALYTIC PROCESS FOR THE DIRECT PRODUCTION OF LIGHT NAPHTHA FROM CARBOHYDRATE-CONTAINING FEEDSTOCK
  申请人：Katholieke Universiteit Leuven, K.U. Leuven Research & Development

  公开号：US20170190978A1

  公开（公告）日：2017-07-06

  The disclosure describes a one-step liquid biphasic catalytic process for converting a carbohydrate-containing feedstock, preferably lignocellulose, to light naphtha (e.g., hexane, pentane, methyl cyclopentane, cyclohexane, etc.) in the presence of an acidic reactive aqueous phase and a redox catalyst in the organic extracting/reaction phase. The process provides a cost-effective route for producing light-naphtha components, in presence or not of deoxygenates. The light naphtha components are useful as feedstock for steam and catalytic cracking to produce value-added platform molecules like ethylene and propylene, as precursor for the synthesis of bioaromatics like benzene and as gasoline fuel feedstock, and as fuel additives (e.g., the concomitantly formed oxygenates) to improve the biological origin of carbon in the fuel.
• Synthesis, composition and use of novel therapeutic and cosmetic Schiff base products formed by reaction of a carbonyl containing moeity with a transimination nucleophilic catalyst and the use of transimination nucleophilic catalysts to increase the rate at which carbonyl containing therapeutic and cosmetic actives form Schiff base products with biological amines
  申请人：Isaacman Steven

  公开号：US09365532B1

  公开（公告）日：2016-06-14

  The present invention relates to the synthesis, composition and use of novel moieties formed by reacting a transimination nucleophilic catalyst, molecular or polymeric, with carbonyl-containing therapeutic or cosmetic moieties. The resultant Schiff base product is highly reactive towards transimination with a biological amine. The catalyst and carbonyl-containing moiety can be molecular or polymeric, and the resultant chemical and physical properties of the Schiff base products can be engineered by appropriate selection of said catalyst. The present invention also relates to the synthesis, composition and use of novel moieties that are used as actives in sunless tanning preparations. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate at which a carbonyl-containing moiety reacts with a biological amine. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate and efficacy of commercial sunless tanning preparations. Improvements on stability and efficacy of said preparations are disclosed. While the invention has been described in terms of its preferred embodiments, those skilled in the art will recognize that the invention can be practiced with modification within the spirit and scope of the appended claims. Accordingly, the present invention should not be limited to the embodiments as described above, but should further include all modifications and equivalents thereof within the spirit and scope of the description provided herein.

  本发明涉及通过将转移胺亲核催化剂（分子或聚合物）与含羰基的治疗或化妆品基团反应而形成的新颖基团的合成、组成和使用。所得的席夫碱产物对生物胺的转移胺反应具有高度的反应性。催化剂和含羰基基团可以是分子或聚合物，并且通过适当选择所述催化剂可以调控席夫碱产物的化学和物理性质。本发明还涉及合成、组成和使用作为无阳光晒黑制剂中活性成分的新颖基团。本发明还涉及使用转移胺亲核催化剂来增加含羰基基团与生物胺反应的速率。本发明还涉及使用转移胺亲核催化剂来提高商业无阳光晒黑制剂的速率和功效。所述制剂的稳定性和功效的改进被披露。虽然本发明已根据其首选实施方式进行了描述，但技术领域的专业人士将认识到，本发明可以在附图权利要求的精神和范围内进行修改实施。因此，本发明不应仅限于上述描述的实施方式，而应进一步包括本文所提供的描述的精神和范围内的所有修改和等效物。