1-Amino-3-heptanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Amino-3-heptanol
• 英文别名: 1-Aminoheptan-3-ol
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: GXMSOADYSNPWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-氯戊醛 、 1-Amino-3-heptanol 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 (+/-)-(2R*,9aS*)-Hexahydro-2-butyl-2H,6H-pyrido<2,1-b><1,3>oxazine 、 (+/-)-(2R*,9aR*)-Hexahydro-2-butyl-2H,6H-pyrido<2,1-b><1,3>oxazine
  参考文献：
  名称：

  Conformational Considerations in 1-Oxaquinolizidines Related to the Xestospongin/Araguspongine Family: Reassignment of Stereostructures for Araguspongines B and E

  摘要：

  Conformational aspects of the 1-oxaquinolizidine ring system found in the xestospongin/araguspongine family of natural products has been studied by molecular modeling and NMR spectroscopy. Stereochemical complexities [e.g., (i) cis- vs trans-decalin-like conformers and (ii) relative configuration of variously substituted 1-oxaquinolizidines] associated with this bridgehead nitrogen-containing skeleton are discussed. Experimental equilibrium values are rationalized. Reassignment of the stereostructures for araguspongines B (from 4 to 6) and E (from 5 to 2) is made in light of the above.

  DOI：

  10.1021/jo00102a012

文献信息

• Two-component urethane coating system
  申请人：The Lubrizol Corporation

  公开号：EP0094196A2

  公开（公告）日：1983-11-16

  The present invention contemplates the provision of two-component urethane coating compositions comprising a first component comprising an organic polyfunctional isocyanate, and a second component comprising an acidic ester of a phosphoric acid, the alcohol portions of said acidic acid being selected from the group consisting of hydrocarbyloxy and hydroxysubstituted hydrocarbyloxy compounds, such compositions providing enhanced corrosion resistance properties as well as improved flame retardency and metal adhesion characteristics over the two-component urethane systems of the prior art. An essential ingredient in the compositions of the invention is a non-Newtonian colloidal disperse system which can be provided with either the first component and/or the second component parts of the compositions of the invention. The non-Newtonian colloidal disperse systems provided in accordance with the present invention comprise (1) solid metal-containing colloidal particles predispersed in (2) a disperse medium of at least one inert organic liquid and (3) as an essential third component at least one member selected from the class consisting of organic compounds which are substantially soluble in said disperse medium, the molecules of said organic compound being characterized by polar substituents and hydrophobic portions. The invention also relates to a method of coating a substrate comprising mixing the foregoing components and depositing the resulting composition on said substrate.

  本发明考虑提供双组分聚氨酯涂料组合物，其第一组分包括有机多官能团异氰酸酯，第二组分包括磷酸的酸性酯，所述酸性酸的醇部分选自烃比氧基和羟基取代烃比氧基化合物组成的组，与现有技术的双组分聚氨酯体系相比，这种组合物具有更强的耐腐蚀性能，以及更好的阻燃性和金属粘附性。本发明组合物中的一种重要成分是非牛顿胶体分散系统，它可以与本发明组合物的第一组分和/或第二组分一起提供。根据本发明提供的非牛顿胶体分散体系包括：(1) 预先分散在 (2) 至少一种惰性有机液体的分散介质中的含金属固体胶体颗粒；(3) 作为重要的第三组分，至少一种选自有机化合物类别的成员，这些有机化合物基本上可溶于所述分散介质，所述有机化合物的分子具有极性取代基和疏水部分。本发明还涉及一种涂覆基质的方法，包括混合上述组分并将所得组合物沉积在所述基质上。
• Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability
  申请人：TLC THERAPEUTICS, LLC

  公开号：US10940155B2

  公开（公告）日：2021-03-09

  A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

  本发明提供了一种用于口服的富马酸喹硫平组合物，该组合物包含喹硫平的药学上可接受的盐或溶液，以悬浮液的形式存在于水性载剂中。本发明的液体制剂具有与已批准的剂型一致的高生物利用度、低结块、减少固体口服剂型中常用赋形剂的含量以及延长保质期的稳定性。本发明还提供了一种用于口服的液体喹硫平悬浮组合物的制造方法，以及向有需要的患者施用治疗有效剂量的口服液体喹硫平悬浮组合物的方法。
• EP1161511A4
  申请人：——

  公开号：EP1161511A4

  公开（公告）日：2003-01-02
• APHRON-CONTAINING OIL BASE FLUIDS AND METHOD OF DRILLING A WELL THEREWITH
  申请人：Masi Technologies L.L.C.

  公开号：EP1161511B1

  公开（公告）日：2004-09-15
• METHOD OF GENERATING GAS BUBBLES IN OLEAGINOUS LIQUIDS
  申请人：Actisystems, Inc.

  公开号：EP1276552A2

  公开（公告）日：2003-01-22