N-(pyridin-2-yl)heptanamide | 91973-36-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(pyridin-2-yl)heptanamide
• 英文别名: N-(2-pyridyl) heptanamide；N-2-Pyridinylheptanamide；N-pyridin-2-ylheptanamide
• CAS: 91973-36-3
• 化学式: C₁₂H₁₈N₂O
• mdl: MFCD03364038
• 分子量: 206.288
• InChiKey: QMJOUBIJCIKUJA-UHFFFAOYSA-N

物化性质

• 沸点：
  386.9±15.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 正庚醇 在 叔丁基过氧化氢 、 1-(3-sulfopropyl)pyridinium phosphotungstate 作用下， 以 水 为溶剂， 反应 1.0h， 以68%的产率得到N-(pyridin-2-yl)heptanamide
  参考文献：
  名称：

  杂多阴离子基离子液体通过双功能催化过程催化醇与胺的高效，生态友好和可持续的串联氧化酰胺化

  摘要：

  已经报道了一种有效的，生态友好的和可持续的方法，用于醇与胺的串联氧化酰胺化。使用基于杂多阴离子的离子液体作为催化剂，使用叔丁基氢过氧化物作为氧化剂，该酰胺化反应操作简单，并以中等至良好的产率提供了一系列伯，仲和叔酰胺衍生物。无溶剂介质，微波促进条件和催化剂的可重复使用性是主要亮点。此外，在本报告中已对所提出的双功能催化机理进行了简要研究。

  DOI：

  10.1016/j.tet.2016.11.002

文献信息

• Microwave-assisted heteropolyanion-based ionic liquid promoted sustainable protocol to N-heteroaryl amides via N-directing dual catalyzed oxidative amidation of aldehydes
  作者：Renzhong Fu、Yang Yang、Weihua Jin、Hui Gu、Xiaojun Zeng、Wen Chai、Yunsheng Ma、Quan Wang、Jun Yi、Rongxin Yuan

  DOI：10.1039/c6ra20961k

  日期：——

  A procedure for the synthesis of N-heteroaryl amides directly from oxidative amidation of aldehydes catalyzed by heteropolyanion-based ionic liquids has been reported. The proposed N-directing dual-catalysis mechanism was briefly investigated.

  报告了一种在杂多阴离子基离子液体催化下直接从醛的氧化酰胺化反应合成 N-杂芳基酰胺的方法。对所提出的 N-定向双催化机理进行了简要研究。
• Copper(<scp>i</scp>)-catalysed oxidative C–N coupling of 2-aminopyridine with terminal alkynes featuring a CC bond cleavage promoted by visible light
  作者：Ayyakkannu Ragupathi、Arunachalam Sagadevan、Chun-Cheng Lin、Jih-Ru Hwu、Kuo Chu Hwang

  DOI：10.1039/c6cc05506k

  日期：——

  Facile visible-light promoted copper-catalyzed aerobic oxidative C-N coupling between 2-aminopyridine and terminal alkynes at room temperature via CC triple bond cleavage is described. This reaction allows direct synthesis of biologically...

  描述了在室温下通过CC三键裂解在2-氨基吡啶和末端炔烃之间促进可见光促进的铜催化的需氧氧化CN偶联。该反应可以直接合成生物...
• Ru-Catalyzed Hydroamidation of Alkenes and Cooperative Aminocarboxylation Procedure with Chelating Formamide
  作者：Sangwon Ko、Hoon Han、Sukbok Chang

  DOI：10.1021/ol034862r

  日期：2003.7.1

  A strategy of chelation-assisted activation of formamide was employed to achieve hydroamidation of alkenes to generate one-carbon-elongated amides in moderate to good selectivity and yields. Also reported is the two-metal-catalyzed cooperative aminocarboxylation of aryl iodides, in which Ru is presumed to catalyze decarbonylation of formamide to release carbon monoxide and amine for the subsequent Pd-catalyzed aminocarboxylation routes, thus enabling the net transformation to be performed in the absence of external CO pressure.
• IMIDAZO[1,2-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20210053973A1

  公开（公告）日：2021-02-25

  Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof: wherein: “Z” and R1 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
• An efficient, eco-friendly and sustainable tandem oxidative amidation of alcohols with amines catalyzed by heteropolyanion-based ionic liquids via a bifunctional catalysis process
  作者：Renzhong Fu、Yang Yang、Wei Feng、Qiuxia Ge、Yan Feng、Xiaojun Zeng、Wen Chai、Jun Yi、Rongxin Yuan

  DOI：10.1016/j.tet.2016.11.002

  日期：2016.12

  eco-friendly and sustainable method for the tandem oxidative amidation of alcohols with amines has been reported. Using heteropolyanion-based ionic liquids as the catalyst and tert-butyl hydroperoxide as the oxidant, this amidation reaction is operationally straightforward and provides a series of primary, secondary and tertiary amides derivatives in moderate to good yields. Solvent-free media, microwave-promoted

  已经报道了一种有效的，生态友好的和可持续的方法，用于醇与胺的串联氧化酰胺化。使用基于杂多阴离子的离子液体作为催化剂，使用叔丁基氢过氧化物作为氧化剂，该酰胺化反应操作简单，并以中等至良好的产率提供了一系列伯，仲和叔酰胺衍生物。无溶剂介质，微波促进条件和催化剂的可重复使用性是主要亮点。此外，在本报告中已对所提出的双功能催化机理进行了简要研究。