3β-ethoxymethoxy-5-cholestene

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-ethoxymethoxy-5-cholestene
• 英文别名: 3beta-Ethoxymethoxy-5-cholestene；(3S,8S,9S,10R,13R,14S,17R)-3-(ethoxymethoxy)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
• 化学式: C₃₀H₅₂O₂
• 分子量: 444.742
• InChiKey: NANPCXQWCADOHY-OCBUSCMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二乙氧基甲烷 、 胆固醇 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 以79%的产率得到3β-ethoxymethoxy-5-cholestene
  参考文献：
  名称：

  Efficient and Selective Formation of Mixed Acetals by Nafion‐H SAC‐13 Silica Nanocomposite Solid Acid Catalyst

  摘要：

  Various types of hydroxy compounds can readily be converted to the corresponding mixed acetals with dialkoxymethanes in the presence of SAC-13 solid superacid. The transformation is almost instantaneous, product acetals are isolated in good to excellent yields, and the catalyst can be reused with minor loss of activity. Comparative studies were also carried out with p-toluenesulfonic acid and BF3 (.) OEt2.

  DOI：

  10.1081/scc-200032419

文献信息

• Microbiological degradation of sterol side chains to a 17-keto group
  申请人：Schering Aktiengellschaft

  公开号：US04179336A1

  公开（公告）日：1979-12-18

  The side chains of sterols are degraded by fermentation with microorganisms capable of doing so in an improved manner by employing in such fermentations sterol derivatives of the formula ##STR1## wherein n is 1 or 2; R.sub.1 is H or lower alkyl, R.sub.2 is alkyl, whose chain optionally is interrupted by an oxygen atom, or when n is 2, also a hydrogen atom; and R.sub.3 is a sterol side chain.

  类固醇的侧链通过使用能够进行这种改进的微生物发酵降解，通过在这种发酵中使用如下公式的类固醇衍生物来实现：##STR1## 其中n为1或2; R.sub.1为H或较低的烷基，R.sub.2为烷基，其链可选择性地被氧原子中断，或当n为2时，也可为氢原子; R.sub.3为类固醇侧链。
• Efficient and Selective Formation of Mixed Acetals by Nafion‐H SAC‐13 Silica Nanocomposite Solid Acid Catalyst
  作者：István Ledneczki、Árpád Molnár

  DOI：10.1081/scc-200032419

  日期：2004.1.1

  Various types of hydroxy compounds can readily be converted to the corresponding mixed acetals with dialkoxymethanes in the presence of SAC-13 solid superacid. The transformation is almost instantaneous, product acetals are isolated in good to excellent yields, and the catalyst can be reused with minor loss of activity. Comparative studies were also carried out with p-toluenesulfonic acid and BF3 (.) OEt2.
• US4179336A
  申请人：——

  公开号：US4179336A

  公开（公告）日：1979-12-18