cholesteryl hemisuccinate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesteryl hemisuccinate
• 英文别名: 4-(Cholest-5-en-3-yloxy)-4-oxobutanoic acid；4-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid
• 化学式: C₃₁H₅₀O₄
• 分子量: 486.736
• InChiKey: WLNARFZDISHUGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cholesteryl hemisuccinate 、 2,4-二羟基苯甲醛 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以59%的产率得到4-cholesteryl hemisuccinate-salicylaldehyde
  参考文献：
  名称：

  Lipophilic ruthenium salen complexes: incorporation into liposome bilayers and photoinduced release of nitric oxide

  摘要：

  我们报告了将一种新的亲脂性Ru salen配合物有效地纳入脂质体双层结构中，并实现了光控释放和输送一氧化氮。

  DOI：

  10.1039/c5dt02352a
• 作为产物：
  描述：

  丁二酸酐 、 cholesterol 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 生成 cholesteryl hemisuccinate
  参考文献：
  名称：

  Lipophilic ruthenium salen complexes: incorporation into liposome bilayers and photoinduced release of nitric oxide

  摘要：

  我们报告了将一种新的亲脂性Ru salen配合物有效地纳入脂质体双层结构中，并实现了光控释放和输送一氧化氮。

  DOI：

  10.1039/c5dt02352a

文献信息

• [EN] COMPOSITIONS FOR INDUCING TUMOR IMMUNITY AND REDUCING DRUG TOLERANCE<br/>[FR] COMPOSITIONS POUR INDUIRE UNE IMMUNITÉ TUMORALE ET RÉDUIRE LA TOLÉRANCE AUX MÉDICAMENTS
  申请人：BRIGHAM & WOMENS HOSPITAL INC

  公开号：WO2022082108A1

  公开（公告）日：2022-04-21

  Described herein are HSP-90 inhibitors conjugated to lipids, compositions comprising the conjugates, and methods of use thereof for treating cancer.

  本文描述了与脂质结合的HSP-90抑制剂，包括该结合物的组合物，以及使用该组合物治疗癌症的方法。
• Imino compounds for amphoteric liposomes and uses thereof
  申请人：NOVOSOM VERWALTUNGS GMBH

  公开号：US10039714B2

  公开（公告）日：2018-08-07

  The invention concerns lipid assemblies, liposomes having an outer surface comprising a mixture of anionic and cationic moieties; wherein at least a portion of the cationic moieties are imino moieties that are essentially charged under physiological conditions, and their use for serum resistant transfection of cells.

  本发明涉及脂质组合物，脂质体的外表面包含阴离子和阳离子的混合物；其中阳离子至少有一部分是亚氨基，在生理条件下基本上是带电的，本发明还涉及脂质体在细胞抗血清转染中的应用。
• LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：Novartis AG

  公开号：EP2964608B1

  公开（公告）日：2019-08-28
• AMPHOTERIC LIPOSOMES COMPRISING NEUTRAL LIPIDS
  申请人：Panzner Steffen

  公开号：US20100330154A1

  公开（公告）日：2010-12-30

  An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
• PH-RESPONSIVE LIPOSOME
  申请人：Takeoka Shinji

  公开号：US20120064148A1

  公开（公告）日：2012-03-15

  The present invention provides pH-responsive liposomes which are capable of holding a desired substance in an acidic pH environment and releasing the desired substance in a basic pH environment. The present invention uses pH-responsive liposomes comprising, as constituent lipids thereof, a cationic amphiphilic molecule and at least one of an anionic amphiphilic molecule and a twitterionic amphiphilic molecule, wherein the liposomes, when dispersed in an aqueous medium, have a positive zeta potential in an acidic environment where the dispersion has a pH of less than 6.5 and have a negative zeta potential in a basic environment where the dispersion has a pH of 8.5 or more.