1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)urea
• 英文别名: (3-Hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)urea
• 化学式: C₁₃H₁₈N₂O₄
• 分子量: 266.297
• InChiKey: JDASGLHCBMMURM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  93.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  potassium cyanate 、 以 水 为溶剂， 反应 1.0h， 以90%的产率得到1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)urea
  参考文献：
  名称：

  Synthesis, hypotensive and antiarrhythmic activities of 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues

  摘要：

  A series of new 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues was synthesized from corresponding 3-amino-l,2,3,4-tetrahydronaphthalenes. Pharmacological tests showed that compounds 3-ethyl-1-(2-hydroxy-5,8-dimethoxy- 1,2,3,4-tetrahydro-3-naphthalenyl)urea 2a and 3-ethyl-l-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro3-naphthalenyl)-3-morpholinomethylurea 3a possessed pronounced hypotensive and antiarrhythmic activities, as tested in anesthetized rats. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80022-1

文献信息

• Synthesis, hypotensive and antiarrhythmic activities of 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues
  作者：Elena G. Chalina、Lidia Chakarova

  DOI：10.1016/s0223-5234(99)80022-1

  日期：1998.12

  A series of new 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues was synthesized from corresponding 3-amino-l,2,3,4-tetrahydronaphthalenes. Pharmacological tests showed that compounds 3-ethyl-1-(2-hydroxy-5,8-dimethoxy- 1,2,3,4-tetrahydro-3-naphthalenyl)urea 2a and 3-ethyl-l-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro3-naphthalenyl)-3-morpholinomethylurea 3a possessed pronounced hypotensive and antiarrhythmic activities, as tested in anesthetized rats. (C) Elsevier, Paris.