3-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one
• 英文别名: 3-phenyl-3,5,6,7-tetrahydro-2H-1-benzofuran-4-one
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: ZZBBNHSPMNXTIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲醛 在 potassium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 6.0h， 生成 3-phenyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one
  参考文献：
  名称：

  An efficient, transition-metal-free process for the synthesis of substituted dihydrofurans via a Michael/cyclization tandem reaction

  摘要：

  An efficient green route for the synthesis of substituted dihydrofurans was developed through a simple base-catalyzed, tandem reaction of nitrostyrene with 1,3-dicarbonyl compounds. The desired products were prepared with a large substrate scope and in excellent yields (up to 95%). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.151

文献信息

• An efficient, transition-metal-free process for the synthesis of substituted dihydrofurans via a Michael/cyclization tandem reaction
  作者：Ming-Yu Wu、Ming-Qi Wang、Kun Li、Xing-Wen Feng、Ting He、Na Wang、Xiao-Qi Yu

  DOI：10.1016/j.tetlet.2010.11.151

  日期：2011.2

  An efficient green route for the synthesis of substituted dihydrofurans was developed through a simple base-catalyzed, tandem reaction of nitrostyrene with 1,3-dicarbonyl compounds. The desired products were prepared with a large substrate scope and in excellent yields (up to 95%). (C) 2010 Elsevier Ltd. All rights reserved.