1-phenylprop-2-en-1-amine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-phenylprop-2-en-1-amine hydrochloride
• 英文别名: 1-Phenylprop-2-enylazanium;chloride；1-phenylprop-2-enylazanium;chloride
• 化学式: C₉H₁₁N*ClH
• 分子量: 169.654
• InChiKey: SMLXICHDYHVTSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-phenylprop-2-en-1-amine hydrochloride 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 N-benzyl-N-(2-bromoprop-2-enyl)-1-phenylprop-2-en-1-amine
  参考文献：
  名称：

  镍促进氨基溴代双烯的串联环化猝灭的非对映异构控制的吡咯烷合成

  摘要：

  镍促进的束缚氨基溴二茂铁的串联环化淬灭反应已扩展到2,3,4-三取代吡咯烷的合成。通过明智地选择起始氨基卤代二烯上的取代基，可以有效地控制该方法的非对映选择性。当使用氮原子上的手性助剂时，除去助剂后可获得对映体富集的吡咯烷。

  DOI：

  10.1016/s0040-4020(97)10220-4
• 作为产物：
  描述：

  1-(1-imino-2,2,2-trichloroethoxy)-3-phenyl-2(E)-propene 在 sodium hydroxide 作用下， 以 乙醇 、 xylene 为溶剂， 反应 40.0h， 生成 1-phenylprop-2-en-1-amine hydrochloride
  参考文献：
  名称：

  Synthesis of Pharmacologically Relevant Indoles with Amine Side Chains via Tandem Hydroformylation/Fischer Indole Synthesis

  摘要：

  The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

  DOI：

  10.1021/jo050464l

文献信息

• One‐Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp ³ C−H Imination
  作者：Subrata K. Ghosh、Mengnan Hu、Robert J. Comito

  DOI：10.1002/chem.202102627

  日期：2021.12.15

  One for all: We report the sp3 C−H imination of simple alkanes and functionalized molecules, which provides primary amines on workup. Our method shows good site selectivity and functional group tolerance, which we have used for the synthesis of complex amines. We characterize a unique mechanism involving radical rebound to imine.

  一个用于所有：我们报告的SP 3简单烷烃和官能分子的C-H亚胺化，这提供了关于后处理的伯胺。我们的方法显示出良好的位点选择性和官能团耐受性，我们已将其用于复杂胺的合成。我们描述了一种独特的机制，涉及到亚胺的自由基反弹。
• anti Selective dihydroxylation by the ketimine derivatives of the allylic amine in monosubstituted olefins
  作者：Joon Seok Oh、Doh Yeon Park、Bu Sop Song、Jae Gwang Bae、Seung Woong Yoon、Young Gyu Kim

  DOI：10.1016/s0040-4039(02)01654-4

  日期：2002.9

  Transformation of the allylic amine of monosubstituted olefins into the aryl ketimine derivatives resulted in consistent higher anti diastereofacial selectivity in the osmium-catalyzed dihydroxylation reactions, compared to the selectivities obtained from commonly used allylic amino derivatives such as N-acyl, N-Boc or N,N-dibenzyl. The anti selectivity ranged from 3:1 to 7:1 in dry THF and the best

  与从常用的烯丙基氨基衍生物（例如N-酰基，N -Boc或N）获得的选择性相比，单取代烯烃的烯丙基胺向芳基酮亚胺衍生物的转化导致在consistent催化的二羟基化反应中始终具有更高的抗非对映选择性。，ñ二苄。在干THF中的抗选择性范围为3：1至7：1，使用3,3'-二氟二苯甲酮酮亚胺衍生物观察到的最佳选择性。还报道了在具有生物学重要性的底物上应用酮亚胺基。
• PHOSPHORAMIDITE LIGAND AND PRODUCTION METHOD OF ALLYLIC AMINE USING THE SAME
  申请人：CARREIRA Erick M.

  公开号：US20090054689A1

  公开（公告）日：2009-02-26

  The present invention provides a production method of an allylic amine represented by the formula (III): wherein R 3 is as defined in the specification, which comprises reacting by an allylic alcohol represented by the formula (II): wherein R 3 is as defined in the specification, with sulfamic acid, in the presence of a phosphoramidite ligand represented by the formula (I): wherein each symbol is as defined in the specification, and an iridium complex. According to the present invention, a primary allylic amine can be produced directly from an allylic alcohol, without use of an activator for an allylic alcohol and conversion of an allylic alcohol into an activated compound thereof.

  本发明提供了一种制备烯丙胺的生产方法，烯丙胺的化学式为(III)，其中R3如规范中定义，该方法包括使用磷酰胺配体(I)和铱配合物，在磺酸的存在下，将烯丙醇(II)与磺酸反应。根据本发明，可以直接从烯丙醇中生产出主要的烯丙胺，而无需使用烯丙醇的活化剂，也无需将烯丙醇转化为其活化化合物。
• Heat-developable color photographic materials
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0118078A2

  公开（公告）日：1984-09-12

  A heat-developable color photographic material is disclosed. The material is comprised of a support base, a binder, a light-sensitive silver halide, a dye releasing redox compound which reduces the light-sensitive silver halide and releases a hydrophilic dye by reacting with the light-sensitive silver halide by heating; and a base precursor. The base precursor is represented by the general formula: wherein the substituents are defined within the specification. The material is capable of forming dye images with high density by heating the material after exposure in a substantially water free state. The images can be obtained in a short period of time and maintain their color density during storage. Further, the material produces a relatively low degree of fog based on the high degree of image density obtained.

  本发明公开了一种可加热显影的彩色感光材料。该材料由支撑基底、粘合剂、感光卤化银、染料释放氧化还原化合物（该化合物可还原感光卤化银，并通过加热与感光卤化银反应释放亲水性染料）和基底前体组成。碱前体由通式表示： 其中取代基在说明书中定义。该材料在基本不含水的状态下曝光后，通过加热可形成高密度的染料图像。这些图像可在短时间内获得，并在储存期间保持其色彩密度。此外，在获得高密度图像的基础上，该材料产生的雾度相对较低。
• Heat developable color light-sensitive materials
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0120661A2

  公开（公告）日：1984-10-03

  Heat developable color-image forming material has a layer containing (a) light-sensitive silver halide grains (b) a redox compound having a hydrophilic releasable dye moiety and a reducing group which, on heating, reduces imagewise exposed silver halide, mobile dye being then released, and (c) a compound which, on heating, releases a base, of a general formula: the A groups being H or specified aliphatic or cyclic groups and X being a nucleophilic group. Compound (C) preferably is 0.01-30 % by weight of the coating(s); 50 compounds are shown, with synthesis examples. Other basic substances or precursors can be present. Development is by dry heating at 80°-250°C. to form a silver image and dye image which is transferred to unitary or separate fixing layer. The material has good storage life and gives dye images of high density.

  可加热显影的彩色图像形成材料有一层，其中含有 (a) 光敏卤化银颗粒 (b) 氧化还原化合物，该化合物具有亲水性可释放染料分子和还原基团，加热时可还原图像上暴露的卤化银，然后释放流动染料，以及 (c) 通式为加热时释放碱的化合物： 其中 A 基团为 H 或特定的脂肪族或环状基团，X 为亲核基团。 化合物（C）最好占涂层重量的 0.01-30%；图中有 50 种化合物，并附有合成实例。也可以含有其他基本物质或前体。 显影方法是在 80°-250°C 下干热，形成银像和染料像，然后转印到单元或单独的定影层上。 这种材料具有良好的储存寿命，并能产生高密度的染料图像。