2-(methyldisulfanyl)benzo[d]thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(methyldisulfanyl)benzo[d]thiazole
• 英文别名: 2-(Methyldisulfanyl)-1,3-benzothiazole
• 化学式: C₈H₇NS₃
• 分子量: 213.348
• InChiKey: VZYUDIZFTNJCIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  91.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-巯基苯并噻唑 在 palladium dichloride 作用下， 以 二甲基亚砜 为溶剂， 反应 4.0h， 生成 2-(methyldisulfanyl)benzo[d]thiazole
  参考文献：
  名称：

  PdCl 2 / DMSO催化的巯基-二硫键交换：不对称二硫键的合成

  摘要：

  通过使用简单的PdCl 2 / DMSO催化系统与对称的二硫化物进行硫醇交换，可以有效地制备不对称的二硫化物。给定的方法具有出色的官能团耐受性，广泛的底物范围和操作简便性。该反应对于诸如肽和药物之类的生物活性支架的后期功能化特别有用。还已经制备了含二硫化物的有机染料。这种转化可以扩展到硫醇-二硒化物或硫醇-二碲化物交换，从而提供RS-SeR'或RS-TeR'。

  DOI：

  10.1021/acs.orglett.1c00858

文献信息

• Direct methylthiolation of <i>C</i>-, <i>S</i>-, and <i>P</i>-nucleophiles with sodium <i>S</i>-methyl thiosulfate
  作者：Fanmin Liu

  DOI：10.1039/d2ob02056d

  日期：——

  A practical and efficient methylthiolation that employed the typical Bunte salt sodium S-methyl sulfothioate as the sulfur source was described. This reagent could react with a variety of compounds such as alkynes, 1,3-diketones, thiols, selenol and H-phosphine oxides, affording methylthiolated products in moderate to excellent yields. The advantages such as easy preparation, air- and moisture-stability

  描述了使用典型的 Bunte 盐S-甲基硫代磺酸钠作为硫源的实用且有效的甲基硫醇化。该试剂可以与多种化合物反应，如炔烃、1,3-二酮、硫醇、硒醇和H-氧化膦，以中等至优异的收率提供甲基硫醇化产物。制备简单、空气和水分稳定、官能团耐受性高等优点表明该试剂具有广泛应用于有机合成的潜力。值得注意的是，厄洛替尼药物分子的后期修饰证明了该试剂的稳健性。
• Deodorized compositions
  申请人：MONSANTO COMPANY

  公开号：EP0128891A2

  公开（公告）日：1984-12-19

  Deodorized compositions are described comprising an intimate mixture of a malodorous sulfur containing compound and activated carbon.

  所述除臭组合物由恶臭含硫化合物和活性炭的亲密混合物组成。
• BIOACTIVE SUBSTANCE-BLOOD PROTEIN CONJUGATE AND STABILIZATION OF A BIOACTIVE SUBSTANCE USING THE SAME
  申请人：Park Jong-Il

  公开号：US20100021480A1

  公开（公告）日：2010-01-28

  This invention relates to a technology of modifying low-molecular-weight bioactive substances with short in vivo half-life and low stability in order to achieve a stable and efficient in vivo delivery thereof. More specifically, the present invention relates to a stable bioactive substance-blood protein conjugate, wherein a low-molecular-weight bioactive substance is ex vivo conjugated with a specific functional group on a blood protein through a reactive group, the low-molecular-weight bioactive substance is available as a drug for treatment and prevention in mammals including human and selected from the group consisting of a natural substance; and a method of a stable and efficient in vivo delivery of the low-molecular-weight bioactive substance based on the use of the bioactive substance-blood protein conjugate.
• LAMINATED BODY AND CIRCUIT WIRING BOARD
  申请人：Mori Kunio

  公开号：US20110104505A1

  公开（公告）日：2011-05-05

  Provided is a laminated body which solves, all at once, the issues of conventional methods, such as adhesiveness to a board having low surface roughness, stress concentration relaxing, reliability improvement, high adhesiveness (especially, that of a conductor layer), heat resistance, almighty characteristics (being adherable irrespective of the type of an adhesive), in manufacture of laminated bodies. The laminated body is formed by having an entropically elastic molecular adhesive layer between two boards, and the entropically elastic molecular adhesive layer is composed of an entropically elastic material layer, and a layer of a molecular adhesive having a group which can be bonded to the entropically elastic material layer.
• DETECTION OF PROTEIN S-SULFHYDRATION VIA A TAG-SWITCH TECHNIQUE
  申请人：Washington State University

  公开号：US20150099305A1

  公开（公告）日：2015-04-09

  Methods and assays for detecting S-sulfhydration of amino acids in proteins, polypeptides and peptides are provided. The method is a two-step “tag-switch” method employing two reagents consecutively to specifically label, with a detectable label, persulfide (—S—SH) linkages in proteins, polypeptides and peptides.