17β-(N-diphenylmethylcarbamoyl)androsta-4-ene-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17β-(N-diphenylmethylcarbamoyl)androsta-4-ene-3-one
• 英文别名: 17beta-(N-Diphenylmethylcarbamoyl)androsta-4-ene-3-one；(8S,9S,10R,13S,14S,17S)-N-benzhydryl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-17-carboxamide
• 化学式: C₃₃H₃₉NO₂
• 分子量: 481.678
• InChiKey: ZZYNAUKSQXRBQG-IJSUORRQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  pyridin-2-yl 3-oxo-androst-4-ene-17β-carbothioate 、 二苯甲胺 以the title compound was obtained in a yield of 85%的产率得到17β-(N-diphenylmethylcarbamoyl)androsta-4-ene-3-one
  参考文献：
  名称：

  Steroid derivatives

  摘要：

  发明的化合物##STR1##可用于生产具有5α-还原酶抑制活性的类固醇-17酰胺。

  公开号：

  US05698720A1

文献信息

• Steroid derivatives for the treatment of prostatic hypertrophy their
  申请人：Sankyo Company, Limited

  公开号：US05536714A1

  公开（公告）日：1996-07-16

  The invention includes compounds of formula (I): ##STR1## in which R.sup.1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R.sup.2 is aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R.sup.3 is carboxy or a group of formula --CONHSO.sub.2 R.sup.4 wherein R.sup.4 is alkyl; and pharmaceutically acceptable salts and esters of the compounds. The compounds have valuable 5.alpha.-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5.alpha.-dihydro-testosterone.

  该发明包括式(I)的化合物：##STR1##其中R.sup.1是氢，烷基，芳基取代的烷基或芳香杂环基取代的烷基；R.sup.2是芳基取代的烷基，芳香杂环基取代的烷基或二芳基胺基；R.sup.3是羧基或具有式--CONHSO.sub.2 R.sup.4的基团，其中R.sup.4是烷基；以及该化合物的药用可接受盐和酯。这些化合物具有有价值的5α-还原酶抑制活性，因此可用于治疗和预防前列腺肥大等疾病，以及由于5α-二氢睾酮水平过高而引起的其他疾病。
• Steroid derivatives
  申请人：Sankyo Company, Limited

  公开号：US05698720A1

  公开（公告）日：1997-12-16

  The invented compound ##STR1## is useful for the production of steroidal-17-amides that have 5.alpha.-reductase inhibitory activity.

  发明的化合物##STR1##可用于生产具有5α-还原酶抑制活性的类固醇-17酰胺。
• Steroid derivatives for the treatment of prostatic hypertrophy, their
  申请人：Sankyo Company, Limited

  公开号：US05760025A1

  公开（公告）日：1998-06-02

  Compounds of formula (I): ##STR1## \x9bwherein: R.sup.1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R.sup.2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R.sup.3 is carboxy or a group of formula --CONHSO.sub.2 R.sup.4 wherein R.sup.4 is alkyl!; and pharmaceutically acceptable salts and esters thereof have valuable 5.alpha.-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5.alpha.-dihydrotestosterone.

  式(I)的化合物：##STR1## 其中：R.sup.1是氢、烷基、芳基取代的烷基或芳香族杂环取代的烷基；R.sup.2是芳基取代的烷基、芳香族杂环取代的烷基或二芳基氨基；R.sup.3是羧基或式--CONHSO.sub.2 R.sup.4中的基团，其中R.sup.4是烷基！；以及其药学上可接受的盐和酯具有有价值的5α-还原酶抑制活性，因此可用于治疗和预防前列腺肥大等由过量5α-二氢睾酮水平引起的其他疾病。
• Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0567271A2

  公开（公告）日：1993-10-27

  Compounds of formula (I): [wherein : R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl ; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R3 is carboxy or a group of formula -CONHS02 R4 wherein R4 is alkyl] ; and pharmaceutically acceptable salts and esters thereof have valuable 5α-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5α-dihydro-testosterone.

  式(I)化合物： [其中 ：R1 是氢、烷基、芳基取代的烷基或芳香杂环取代的烷基；R2 是：芳基取代的烷基、芳香杂环取代的烷基或二芳基氨基；以及 R3 是羧基或式 -CONHS02 R4 的基团，其中 R4 是烷基]；及其药学上可接受的盐类和酯类具有重要的 5α 还原酶抑制活性，因此可用于治疗和预防前列腺肥大以及因 5α 二氢睾酮水平过高而引起的其他疾病。
• Compounds suitable for use as intermediates in the preparation of Androst-3,5-dien-3-carboxy derivatives
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0725074A2

  公开（公告）日：1996-08-07

  A compound of formula (IV) and a process for the preparation of a compound of the following formula: in which R10 is a hydroxy group, a group -OR5, in which R5 is a carboxy protecting group, a group -NR1R2, in which R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl and R2 is aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino, or a group -NRR', in which R and R' are hydrogen or alkyl.

  式(IV)化合物 以及制备下式化合物的工艺： 其中 R10 是羟基、基团-OR5（其中 R5 是羧基保护基）、基团-NR1R2（其中 R1 是氢、烷基、芳基取代的烷基或芳香杂环取代的烷基，R2 是芳基取代的烷基、芳香杂环取代的烷基或二芳基氨基）或基团-NRR'（其中 R 和 R' 是氢或烷基）。