F-3-(N,N-dimethylamino)butyryl fluoride

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: F-3-(N,N-dimethylamino)butyryl fluoride
• 英文别名: 4-[Bis(trifluoromethyl)amino]-1,2,2,3,3,4,4-heptafluoro-1-butanone；4-[bis(trifluoromethyl)amino]-2,2,3,3,4,4-hexafluorobutanoyl fluoride
• 化学式: C₆F₁₃NO
• 分子量: 349.051
• InChiKey: IPDUKYVMXONQPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  甲醇 、 F-3-(N,N-dimethylamino)butyryl fluoride 生成 methyl F-3-(N,N-dimethylamino)butyrate
  参考文献：
  名称：

  Electrochemical fluorination of (N,N-dialkylamino)alcohols

  摘要：

  Series of amino alcohols including 2-(N,N-dialkylamino)ethanols, 3-(N,N-dimethylamino)propanol and 4-(N,N-dimethylamino)butanol were subjected to electrochemical fluorination. In the case of 2-(N,N-dialkylamino)ethanols, the F-(2-N, N-dialkylamino) acetyl fluorides were obtained in fair to good yields. Yields of each target compound were strongly dependent on the kind of the dialkylamino group. Cyclic amines having an N-(2-hydroxylethyl) group afforded the corresponding F-[N-(c-alkylamino)-substituted acetyl fluorides]. Their yields were generally better than those of acyclic analogs. Several 2-(N,N-dialkylamino)ethanols and 3-(N,N-dimethylamino)propanol were converted into the corresponding trimethylsilylethers, aminoalkyl methyl carbonates and bis-aminoalkyl carbonate, respectively, and they were subjected to fluorination for a comparison of the yield with that obtained from that of the parent aminoalcohol. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00053-6
• 作为产物：
  描述：

  二甲氨丁醇 在 氢氟酸 作用下， 反应 10.87h， 以17.2%的产率得到七氟丁酰氟
  参考文献：
  名称：

  Electrochemical fluorination of (N,N-dialkylamino)alcohols

  摘要：

  Series of amino alcohols including 2-(N,N-dialkylamino)ethanols, 3-(N,N-dimethylamino)propanol and 4-(N,N-dimethylamino)butanol were subjected to electrochemical fluorination. In the case of 2-(N,N-dialkylamino)ethanols, the F-(2-N, N-dialkylamino) acetyl fluorides were obtained in fair to good yields. Yields of each target compound were strongly dependent on the kind of the dialkylamino group. Cyclic amines having an N-(2-hydroxylethyl) group afforded the corresponding F-[N-(c-alkylamino)-substituted acetyl fluorides]. Their yields were generally better than those of acyclic analogs. Several 2-(N,N-dialkylamino)ethanols and 3-(N,N-dimethylamino)propanol were converted into the corresponding trimethylsilylethers, aminoalkyl methyl carbonates and bis-aminoalkyl carbonate, respectively, and they were subjected to fluorination for a comparison of the yield with that obtained from that of the parent aminoalcohol. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00053-6

文献信息

• PERFLUORINATED 1-ALKOXYPROPENES, COMPOSITIONS, AND METHODS AND APPARATUSES FOR USING SAME
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20200386488A1

  公开（公告）日：2020-12-10

  A perfluorinated 1-alkoxypropene represented by general Formula (I), compositions that include such compounds, and methods and systems that include such compositions are provided, wherein Formula (I) is represented by: R f O—CF═CFCF 3 wherein R f is a linear, branched, or cyclic perfluoroalkyl group having 2 to 10 carbon atoms and optionally further including 1 to 3 nitrogen and/or 1 to 4 oxygen catenary heteroatoms.