2-(pyrrolidin-1-yl)-3-phenylquinazolin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(pyrrolidin-1-yl)-3-phenylquinazolin-4(3H)-one
• 英文别名: 3-phenyl-2-(pyrrolidin-1-yl)quinazolin-4(3H)-one；3-Phenyl-2-pyrrolidin-1-ylquinazolin-4-one
• 化学式: C₁₈H₁₇N₃O
• 分子量: 291.352
• InChiKey: UWQRDRRBZAANQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 N-(2-iodophenyl)-N-phenylmethanediimine 、 molybdenum hexacarbonyl 在 四乙基氯化铵 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以92%的产率得到2-(pyrrolidin-1-yl)-3-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation

  摘要：

  A new, efficient and practical synthesis of quinazolin-4(3H)-ones is reported via molybdenum-mediated cyclocarbonylation using microwave irradiation. These methods allow access to a wide range of quinazolin-4(314)-ones in reasonable yields without the need for gaseous carbon monoxide and palladium catalysts. A range of reactions illustrating the wide scope of this chemistry was carried out and all proceeded in reasonable yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.052

文献信息

• Solid-Phase Synthesis of 3<i>H</i>-Quinazolin-4-ones Based on an Aza Wittig-Mediated annulation Strategy
  作者：José M. Villalgordo、Daniel Obrecht、Alexander Chucholowsky

  DOI：10.1055/s-1998-1971

  日期：1998.12

  Aza Wittig-mediated annulation provides a highly efficient and straightforward strategy for the parallel synthesis of 3H-quinazolin-4-ones on solid support. The products were recovered in good yields and exhibited excellent purities.

  Aza Wittig介导的环化提供了一种高效且直接的策略，用于在固相上并行合成3H-喹唑啉-4-酮。产品以良好的产率回收，并展现了优异的纯度。