2-methylthio-3-methylbenzothiophene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-methylthio-3-methylbenzothiophene
• 英文别名: 3-Methyl-2-methylsulfanyl-1-benzothiophene
• 化学式: C₁₀H₁₀S₂
• 分子量: 194.321
• InChiKey: IQNSNCNKZAEUBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylthio-3-methylbenzothiophene 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 palladium diacetate 、 三乙胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-(2-bromophenyl)-N-[2-(dimethylamino)ethyl]thieno[2,3-b][1]benzothiole-1-carboxamide
  参考文献：
  名称：

  COMPOUND COLLECTIONS, COMPOUNDS AND SYNTHESIS THEREOF

  摘要：

  Provided herein are collections of compounds of formula a) to u), and salts thereof, which have polycyclic aromatic scaffolds and thus have structures targeted towards binding polynucleotide therapeutic targets, including polynucleotide-protein complexes. Also provided are compounds and salts themselves, methods of synthesizing such compounds, methods of identifying compounds having activity against a polynucleotide target, use of the compounds as reference compounds in assays, and phenotypic methods of identifying a new polynucleotide target using the compounds.

  公开号：

  WO2024044825A1
• 作为产物：
  描述：

  3-甲基苯噻吩 在 盐酸 、 sodium hypochlorite 作用下， 以 正己烷 为溶剂， 以97.9%的产率得到2-methylthio-3-methylbenzothiophene
  参考文献：
  名称：

  Benzothiophene/indole-substituted maleimide derivatives, photochromic

  摘要：

  一种新的苯并噻吩/吲哚取代马来酰亚胺衍生物，一种光致变色材料和使用该衍生物的光记录材料。苯并噻吩/吲哚取代马来酰亚胺衍生物由以下化学式（1）或以下化学式（2）表示：其中R是一个取代或未取代的一价碳氢基团，R^1和R^2是氢原子、烷基基团、烷硫基团或烷氧基在至少其中之一为烷硫基团或烷氧基的条件下，R^3是烷基基团或酰基团，环A和环B可能未取代或用烷基基团、烷氧基或卤素原子取代。

  公开号：

  US05468874A1

文献信息

• COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20200338074A1

  公开（公告）日：2020-10-29

  The present disclosure provides combination therapy of a transcription inhibitor and a kinase inhibitor. The combination of the transcription inhibitor and the kinase inhibitor may be useful in treating and/or preventing in a subject a proliferative disease, such as proliferative a disease that is resistant to the transcription inhibitor alone or the kinase inhibitor alone. In certain embodiments, the proliferative disease is a cancer. The combination of the transcription inhibitor and the kinase inhibitor is expected to be synergistic.
• US5468874A
  申请人：——

  公开号：US5468874A

  公开（公告）日：1995-11-21
• Benzothiophene/indole-substituted maleimide derivatives, photochromic
  申请人：Mita Industrial Co., Ltd.

  公开号：US05468874A1

  公开（公告）日：1995-11-21

  A novel benzothiophene/indole-substituted maleimide derivative, a photochromic material and an optical recording material using the same. The benzothiophene/indole-substituted maleimide derivative is represented by the following formula (1): ##STR1## or the following formula (2): ##STR2## wherein R is a substituted or an unsubstituted monovalent hydrocarbon group, R.sup.1 and R.sup.2 are a hydrogen atom, an alkyl group, an alkylthio group or an alkoxy group under the condition where at least either one of them is an alkylthio group or an alkoxy group, R.sup.3 is an alkyl group or an acyl group, and rings A and B may not be substituted or may be substituted with an alkyl group, an alkoxy group or a halogen atom, respectively.

  一种新的苯并噻吩/吲哚取代马来酰亚胺衍生物，一种光致变色材料和使用该衍生物的光记录材料。苯并噻吩/吲哚取代马来酰亚胺衍生物由以下化学式（1）或以下化学式（2）表示：其中R是一个取代或未取代的一价碳氢基团，R^1和R^2是氢原子、烷基基团、烷硫基团或烷氧基在至少其中之一为烷硫基团或烷氧基的条件下，R^3是烷基基团或酰基团，环A和环B可能未取代或用烷基基团、烷氧基或卤素原子取代。
• COMPOUND COLLECTIONS, COMPOUNDS AND SYNTHESIS THEREOF
  申请人：[en]MONASH UNIVERSITY

  公开号：WO2024044825A1

  公开（公告）日：2024-03-07

  Provided herein are collections of compounds of formula a) to u), and salts thereof, which have polycyclic aromatic scaffolds and thus have structures targeted towards binding polynucleotide therapeutic targets, including polynucleotide-protein complexes. Also provided are compounds and salts themselves, methods of synthesizing such compounds, methods of identifying compounds having activity against a polynucleotide target, use of the compounds as reference compounds in assays, and phenotypic methods of identifying a new polynucleotide target using the compounds.