2-amino-2-methylpent-4-en-1-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-2-methylpent-4-en-1-ol
• 化学式: C₆H₁₃NO
• mdl: MFCD19207625
• 分子量: 115.175
• InChiKey: XYPCXDWJRMHUTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-丙烯-1-硼酸 、 羟基丙酮 在 氨 作用下， 以 甲醇 为溶剂， 反应 16.25h， 以80%的产率得到2-amino-2-methylpent-4-en-1-ol
  参考文献：
  名称：

  Diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones

  摘要：

  通过立体选择性的烯丙基化和巴豆基化反应，在原位生成了未取代的N-酮亚胺，进而高效合成了多种叔碳胺。

  DOI：

  10.1039/b511411j

文献信息

• METHODS OF PREPARING TERTIARY CARBINAMINE COMPOUNDS
  申请人：Thadani Avinash N.

  公开号：US20080139847A1

  公开（公告）日：2008-06-12

  The present invention relates to a method for the preparation of tertiary carbinamine compounds from diastereoselective allylation and crotylation of N-unsubstituted imines derived from ketones.

  本发明涉及一种从酮衍生的N-未取代亚胺的立体选择性烯丙基化反应和烯丙基化反应制备三级碳胺化合物的方法。
• Bicyclic sulfonamides
  申请人：ALIGOS THERAPEUTICS, INC.

  公开号：US11033556B2

  公开（公告）日：2021-06-15

  Provided herein are compounds of Formulae (I) and (II), or pharmaceutically acceptable salts of the foregoing, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formulae (I) and/or (II), or a pharmaceutically acceptable salt of any of the foregoing.

  本文提供了式(I)和(II)化合物或前述化合物的药学上可接受的盐、包括本文所述化合物（包括本文所述化合物的药学上可接受的盐）的药物组合物以及合成上述化合物的方法。本文还提供了用式(I)和/或(II)化合物或前述任一化合物的药学上可接受的盐治疗疾病和/或病症的方法。
• BICYCLIC SULFONAMIDES
  申请人：ALIGOS THERAPEUTICS, INC.

  公开号：US20200345749A1

  公开（公告）日：2020-11-05

  Provided herein are compounds of Formulae (I) and (II), or pharmaceutically acceptable salts of the foregoing, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formulae (I) and/or (II), or a pharmaceutically acceptable salt of any of the foregoing.
• US8143451B2
  申请人：——

  公开号：US8143451B2

  公开（公告）日：2012-03-27
• [EN] BICYCLIC SULFONAMIDES<br/>[FR] SULFONAMIDES BICYCLIQUES
  申请人：ALIGOS THERAPEUTICS INC

  公开号：WO2020167984A1

  公开（公告）日：2020-08-20

  Provided herein are compounds of Formulae (I) and (II), or pharmaceutically acceptable salts of the foregoing, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formulae (I) and/or (II), or a pharmaceutically acceptable salt of any of the foregoing.