bis[(2,2,2-trifluoro-1-phenyl)ethyl]amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis[(2,2,2-trifluoro-1-phenyl)ethyl]amine
• 英文别名: 2,2,2-trifluoro-1-phenyl-N-(2,2,2-trifluoro-1-phenylethyl)ethanamine
• 化学式: C₁₆H₁₃F₆N
• 分子量: 333.276
• InChiKey: PNDYKRGPHJSLPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,2,2-三氟乙醛 、 苯 在 六甲基二硅氮烷 、 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 以93%的产率得到bis[(2,2,2-trifluoro-1-phenyl)ethyl]amine
  参考文献：
  名称：

  Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal

  摘要：

  Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields. (C) 2002 Published by Elsevier Science B.V.

  DOI：

  10.1016/s0022-1139(02)00044-1

文献信息

• BIFUNCTIONAL ANALGESIC COMPOUNDS FOR OPIOID RECEPTOR AGONISTS AND NEUROKININ-1 RECEPTOR ANTAGONISTS
  申请人：Hruby Victor

  公开号：US20080039404A1

  公开（公告）日：2008-02-14

  The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.

  本发明提供了一种新型嵌合化合物，其包括在其N-末端具有激动剂阿片受体结合基团和在其C-末端具有拮抗剂神经激肽-1（NK1）受体结合基团，用于产生镇痛作用，以及包括该嵌合化合物的药物组合物、制备该化合物的方法，以及使用该新型嵌合化合物治疗疼痛的方法。
• METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION
  申请人：Japan Tobacco Inc.

  公开号：EP1670446A2

  公开（公告）日：2006-06-21
• US8026218B2
  申请人：——

  公开号：US8026218B2

  公开（公告）日：2011-09-27
• [EN] METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION<br/>[FR] PROCEDE POUR INHIBER LA PRODUCTION DE LIPOPROTEINES RESTANTES
  申请人：JAPAN TOBACCO INC

  公开号：WO2005030185A2

  公开（公告）日：2005-04-07

  The present invention aims to provide for the treatment of hyperlipidemia, arteriosclerosis and hyper-remnant-emia, and to inhibit remnant lipoportein production by adminsetering an inhibitor of CEPT (cholesteryl ester transfer protein). Said inhibitor is a compound selected from the group cosisting of compounds of formula I to fomula XXIII, and compounds selected from the group consisting of JTT-705, CP-529414, SC-795, SC-744, SC-554, SC-71952, SC-56960, SC-57201, PD-140195, WK-5341A, WK-5344B, CETI-1 (CETP Vaccine), BM99-1 and BM99-2.
• Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal
  作者：Yuefa Gong、Katsuya Kato

  DOI：10.1016/s0022-1139(02)00044-1

  日期：2002.8

  Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields. (C) 2002 Published by Elsevier Science B.V.