N,N-dimethyl-2-(phenylselanyl)aniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-2-(phenylselanyl)aniline
• 英文别名: N,N-dimethyl-2-phenylselanylaniline
• 化学式: C₁₄H₁₅NSe
• 分子量: 276.24
• InChiKey: IBUKRIIHNSFJPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯基氯化硒 在 camphor-10-sulfonic acid 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 N,N-dimethyl-2-(phenylselanyl)aniline
  参考文献：
  名称：

  N-Phenylselenosaccharin (NPSSac): a new electrophilic selenium-containing reagent

  摘要：

  A new reagent N-phenylselenosaccharin (NPSSac) was simply prepared and used as a source of the electrophilic phenylselenyl group. This relatively stable new compound was able to react with a series of electron rich organic molecules like alkenes in the presence of external or internal nucleophiles, activated aromatic substrates, or enolizable carbonyl derivatives, under very mild experimental conditions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.08.068

文献信息

• Three-Component Aminoselenation of Arynes
  作者：Rahul N. Gaykar、Avishek Guin、Subrata Bhattacharjee、Akkattu T. Biju

  DOI：10.1021/acs.orglett.9b03789

  日期：2019.12.6

  The three-component coupling of tertiary amines, arynes, and aryl selenium bromide or diaryl diselenide as an electrophilic selenium source allowing the synthesis of 2-selanyl aniline derivatives is reported. This aminoselenation reaction of arynes installs a C-N and C-Se bond under mild conditions, and the products are formed in moderate to good yields. This reaction is compatible with various functional

  据报道，叔胺，芳烃和芳基溴化溴化物或二芳基二硒化物作为亲电子硒源的三组分偶联可以合成2-硒代苯胺衍生物。芳烃的这种氨基硒化反应在温和的条件下安装了CN和C-Se键，并且产物的产率中等至良好。该反应与各种官能团相容，并且还提供了对反应机理的初步研究。