7-methyl-2-[(N-methylanilino)methyl]pyrido[1,2-a]pyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-methyl-2-[(N-methylanilino)methyl]pyrido[1,2-a]pyrimidin-4-one
• 化学式: C₁₇H₁₇N₃O
• 分子量: 279.34
• InChiKey: ZBURIMVPAULINH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PYRIDOPYRIMIDINONES AND THEIR USE AS NMDA RECEPTOR MODULATORS<br/>[FR] PYRIDOPYRIMIDINONES ET LEUR UTILISATION COMME MODULATEURS DU RÉCEPTEUR NMDA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016166078A1

  公开（公告）日：2016-10-20

  The invention relates to pyridopyrimidinone compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, R, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, useful as NMDA receptor modulators in the treatment of neurological and psychiatric conditions.

  这项发明涉及到式（I）的吡啶吡嘧啶酮化合物或其药用盐，其中X、R、R2、R3、R4、R5和R6如本文所定义，以及包含这些化合物的药物组合物，用作NMDA受体调节剂，用于治疗神经系统和精神疾病。
• Pyridopyrimidinones and methods of use thereof
  申请人：Genentech, Inc.

  公开号：US10280165B2

  公开（公告）日：2019-05-07

  The invention relates to pyridopyrimidinone compounds of formula I or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

  本发明涉及式 I 的吡啶嘧啶酮化合物 或其药学上可接受的盐，其中 X、R1、R2、R3、R4、R5 和 R6 如本文所定义，以及包含此类化合物的药物组合物和使用此类化合物的治疗方法。
• PYRIDOPYRIMIDINONES AND THEIR USE AS NMDA RECEPTOR MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3283487B1

  公开（公告）日：2019-10-16
• PYRIDOPYRIMIDINONES AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20180127414A1

  公开（公告）日：2018-05-10

  The invention relates to pyridopyrimidinone compounds of formula I or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.