benzyl phenyl thione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: benzyl phenyl thione
• 英文别名: 1,2-Diphenylethanethione
• 化学式: C₁₄H₁₂S
• 分子量: 212.315
• InChiKey: WGNHYOSRJXYRMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1Z)-2-偶氮基-3-氧代-1,3-二苯基-1-丙烯-1-醇 、 benzyl phenyl thione 以 甲苯 为溶剂， 以78%的产率得到2-benzyl-2,5,6-triphenyl-1,3-oxathiin-4-one
  参考文献：
  名称：

  β-重氮-β-二酮与硫酮反应合成 4H-1,3-oxathiin-4-ones

  摘要：

  通过硫酮与苯甲酰基苯基乙烯酮的环加成反应合成了一系列 2,2-二取代的 5,6-二苯基-4H-1,3-oxathiin-4-ones，苯甲酰苯基乙烯酮是通过 2-diazo-1,3 的热沃尔夫重排生成的-二苯基-1,3-丙二酮。© 2001 John Wiley & Sons, Inc. 杂原子化学 12:630–632, 2001

  DOI：

  10.1002/hc.1095
• 作为产物：
  描述：

  二苯基乙酮 在 di-p-methyoxyphenylthionophosphine sulfide 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以600 mg的产率得到benzyl phenyl thione
  参考文献：
  名称：

  Rearrangements and fragmentations of phenyl styryl sulfides: 1—Metastable ion spectra

  摘要：

  AbstractThe mass spectra of two isomeric phenyl styryl sulphides show abundant peaks for fragment ions formed after interesting and unusual rearrangements, e.g. loss of CHS˙ and C7H7˙. Information about these rearrangements was obtained by comparison of the metastable peak intensities and peak shapes with those of four isomers. It appears that isomerization reactions between the phenyl styryl sulfides and the isomers are possible and that most of the metastable ion fragmentations proceed via reacting configurations that are common to two or more of the compounds investigated. The results indicate that an earlier proposed mechanism for the fragmentation of phenyl vinyl sulfides is incomplete and only partly correct for the compounds studied. Metastable ion spectra were obtained using high voltage scans and constant B/E scans: a short comparison of the results obtained with the two methods is given.

  DOI：

  10.1002/oms.1210170906

文献信息

• Process for the production of fluorinated organic compounds and fluorinating agents
  申请人：——

  公开号：US20030176747A1

  公开（公告）日：2003-09-18

  A process for the production of a fluorinated organic compound, characterized by fluorinating an organic compound having a hydrogen atoms using IF 5 ; and a novel fluorination process for fluorinating an organic compound having a hydrogen atoms by using a fluorinating agent containing IF 5 and at least one member selected from the group consisting of acids, bases, salts and additives.

  一种用IF5对含有氢原子的有机化合物进行氟化的生产过程；以及一种新颖的氟化过程，通过使用含有IF5和来自酸、碱、盐和添加剂组成的至少一种成员的氟化剂对含有氢原子的有机化合物进行氟化。
• METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUND AND FLUORINATING REAGENT
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20150315136A1

  公开（公告）日：2015-11-05

  Object: An object of the present invention is to provide a method for producing, with a high yield, a fluorinated organic compound, the fluorinated organic compound having not been produced with a sufficient yield by a conventional method for producing a fluorinated organic compound using a fluorinating agent containing IF 5 -pyridine-HF alone. Another object of the present invention is to provide a fluorinating reagent. Means for achieving the object: A method for producing a fluorinated organic compound comprising step A of fluorinating an organic compound by bringing the organic compound into contact with (1) IF 5 -pyridine-HF and (2) at least one additive selected from the group consisting of amine hydrogen fluorides, X a F (wherein X a represents hydrogen, potassium, sodium, or lithium), oxidizers, and reducing agents.

  本发明的目的是提供一种高产的制备氟化有机化合物的方法，该氟化有机化合物通过使用仅含有IF5-吡啶-HF的氟化剂制备的传统方法无法获得足够的产量。本发明的另一个目的是提供一种氟化试剂。实现该目的的手段是提供一种制备氟化有机化合物的方法，包括步骤A：通过将有机化合物与(1)IF5-吡啶-HF和(2)至少选择自胺氢氟化物、XaF(其中X代表氢、钾、钠或锂)、氧化剂和还原剂组成的群体中的至少一种添加剂接触来进行氟化。
• Aroylfuranes and aroylthiophenes
  申请人：Eberle Martin

  公开号：US20060205739A1

  公开（公告）日：2006-09-14

  The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

  本发明涉及新的取代的2-(苯基、吡啶基或嘧啶基-羰基)-呋喃和噻吩以及相关的苯氧基/苯硫基-乙酮苯和相应的杂环化合物，其制备方法，含有它们的制药组合物，可选与一种或多种其他药理活性化合物联合使用的治疗肿瘤疾病和自身免疫疾病的用途，以及治疗这种疾病的方法。
• 2-arylbenzo[b]thiophenes useful for the treatment of estrogen deprivation syndrome
  申请人：Eli Lilly and Company

  公开号：US06395769B1

  公开（公告）日：2002-05-28

  This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of formula I:

  本发明提供了使用I式化合物的方法，可用于抑制与雌激素缺乏综合症相关的各种医疗条件，包括骨质疏松和高脂血症。
• 2-arylbenzo[B]thiophenes useful for the treatment of estrogen
  申请人：Eli Lilly and Company

  公开号：US06096781A1

  公开（公告）日：2000-08-01

  This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds of formula I: ##STR1##

  该发明提供了利用I式化合物抑制与雌激素缺乏综合症相关的各种医疗状况的方法，包括骨质疏松和高脂血症。 ##STR1##