1-(pyridin-2-yl)pyrrolidin-2-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(pyridin-2-yl)pyrrolidin-2-ol
• 英文别名: 1-Pyridin-2-ylpyrrolidin-2-ol
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: MQHSURTYQWEPJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3-二氢呋喃 、 2-氨基吡啶 在 cerium(III) chloride heptahydrate 作用下， 以 乙腈 为溶剂， 以88%的产率得到1-(pyridin-2-yl)pyrrolidin-2-ol
  参考文献：
  名称：

  Suresh; Abdul Khader; Chandrasekaran, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 8, p. 999 - 1004

  摘要：

  DOI：

文献信息

• [EN] 2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES AS MELANIN-CONCENTRATING HORMONE RECEPTOR AN TAGONISTS<br/>[FR] 2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES UTILISEES COMME ANTAGONISTES DU RECEPTEUR DE L'HORMONE CONCENTRANT LA MELANINE, ET COMPOSITIONS ET PROCEDES ASSOCIES
  申请人：NEUROCRINE BIOSCIENCES INC

  公开号：WO2005103039A1

  公开（公告）日：2005-11-03

  Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

  黑色素浓缩激素（MCH）受体拮抗剂被披露具有治疗基于MCH受体的疾病如肥胖的效用。本发明的化合物具有以下结构：包括立体异构体、前药和其药用盐，其中R1、R2、R5、Het、X和Cyc如本文所定义。还披露了含有本发明化合物的组合物，以及与其使用相关的方法。
• [EN] THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] COMPOSES DE THIAZOLIDINEDIONE PRESENTANT DES PROPRIETES ANTIDIABETIQUES, HYPOLIPIDEMIANTES, ANTIHYPERTENSIVES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1997041120A1

  公开（公告）日：1997-11-06

  (EN) Novel thiazolidinedione antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuticals acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.(FR) L'invention concerne de nouveaux composés antidiabétiques de thiazolidinedione, leurs formes tautomères, leurs dérivés, leurs stéréoisomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs solvates pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables les contenant, des procédés de préparation des composés antidiabétiques et leurs utilisations.

  (中) 一种新的噻唑烷酮类抗糖尿病化合物、它们的互变异构体、衍生物、立体异构体、多晶形态、药用可接受的盐、药用可接受的溶剂和含有它们的药用可接受的组合物；制备抗糖尿病化合物的方法及其用途。
• Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
  申请人：Goodfellow Val

  公开号：US20050256124A1

  公开（公告）日：2005-11-17

  Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 5 , Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

  本发明揭示了具有治疗MCH受体基础疾病如肥胖症的功效的MCH受体拮抗剂。本发明的化合物具有以下结构：包括立体异构体、前药和其药学上可接受的盐，其中R1、R2、R5、Het、X和Cyc如本文所定义。本发明还揭示了含有本发明化合物的组合物，以及与其使用相关的方法。
• THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：EP0923580A1

  公开（公告）日：1999-06-23
• US5919782A
  申请人：——

  公开号：US5919782A

  公开（公告）日：1999-07-06