全氟-(1-戊基哌啶) | 3113-59-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 全氟-(1-戊基哌啶)
• 英文名称: N-(F-n-pentyl)-F-piperidine
• 英文别名: perfluoro-N-pentylpiperidine；Decafluor-1--piperidin；Perfluor-1-perfluorpentyl-piperidin；Perfluor-1--piperidin；1H-decafluoro-1-undecafluoropentyl-piperidine；perfluoro-(1-pentylpiperidine)；2,2,3,3,4,4,5,5,6,6-decafluoro-1-(1,1,2,2,3,3,4,4,5,5,5-undecafluoropentyl)piperidine
• CAS: 3113-59-5
• 化学式: C₁₀F₂₁N
• 分子量: 533.083
• InChiKey: GDCXYFJTTYCIKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  22

反应信息

• 作为反应物：
  描述：

  全氟-(1-戊基哌啶) 生成 九氟戊酸
  参考文献：
  名称：

  Mazalov,S.A.; Sokolov,S.V., Journal of general chemistry of the USSR, 1966, vol. 36, p. 1344 - 1350

  摘要：

  DOI：
• 作为产物：
  描述：

  1-环戊基哌啶 生成 全氟-(1-戊基哌啶)
  参考文献：
  名称：

  ONO, TAIZO;INOUE, YOSHIHISA;ARAKAWA, YOSHIO;NAITO, YOUICHIRO;FUKAYA, CHIK+, J. FLUOR. CHEM., 43,(1989) N, C. 67-85

  摘要：

  DOI：

文献信息

• Synthesis of perfluorochemicals for use as blood substitutes. Part IV. Electrochemical fluorination of N-cycloalkyl-pyrrolidines and -piperidines
  作者：Taizo Ono、Yoshihisa Inoue、Yoshio Arakawa、Youichiro Naito、Chikara Fukaya、Kouichi Yamanouchi、Kazumasa Yokoyama

  DOI：10.1016/s0022-1139(00)81637-1

  日期：1989.4

  Electrochemical fluorination of N-cyclopentylpyrrolidine gave the corresponding F-amine together with a ring-opened compound N-(F-pentyI)-F-pyrrolidine in the ratio of 1 to 1, in 55% yield. N-cyclohexylpyrrolidine, N-cyclopentylpiperidine, and N-cyclohexylpiperidine were also eletrochemically fluorinated in the same manner to give the corresponding F-amines, their isomers with rearranged structures

  N-环戊基吡咯烷的电化学氟化以1∶1的比例得到相应的F-胺和开环的化合物N-（F-pentyI）-F-吡咯烷，产率为55％。N-环己基吡咯烷，N-环戊基哌啶和N-环己基哌啶也以相同的方式进行电子氟化，得到相应的F-胺，其重排结构的异构体和开环的胺，比率为-4：2：1 ，和2：1：1分别以51％至53％的收率。提供了支持的光谱数据。
• Perfusate for preserving organ to be transplanted and preserving method
  申请人：The Green Cross Corporation

  公开号：EP0033402A1

  公开（公告）日：1981-08-12

  An organ to be transplanted, such as a kidney, can effectively be preserved for an increased period of time by perfusion using a perfusate which is made of a Ringer's solution modified by increasing its potassium ion content to 8-20 meq/liter with a stably emulsified perfluorocarbon compound and dissolved albumin. A preferred concentration of the perfluorocarbon compound, for example perfluorodecalin, is 7.5 to 12.5%(W/V) and that of albumin is 1-8%(W/V) based on the perfusate.

  灌注液是由林格氏溶液改良而成，改良后的林格氏溶液将钾离子含量提高到 8-20 meq/升，并加入了稳定乳化的全氟碳化合物和溶解的白蛋白。全氟碳化合物（例如全氟萘烷）的优选浓度为 7.5-12.5%(W/V)，白蛋白的优选浓度为灌流液的 1-8%(W/V)。
• A nutritive emulsion having oxygen-transporting properties, and process for its preparation
  申请人：Kabi Pharmacia AB

  公开号：EP0220153A1

  公开（公告）日：1987-04-29

  An emulsion of perfluorocarbon compounds in an aqueous system has oxygen transporting properties. By incorpora­tion of fat of animal or vegetable origin and at least one of the amino acids glycine, serine or phenylalanine, or urea in the emulsion, the stability of the emulsion will be increased to a point where it can be sterilized by autoclaving, and have nutritive properties as well. The invention also concerns the preparation of an emulsion stabilized in the above manner.

  全氟碳化合物在水体系中的乳液具有氧气传输特性。通过在乳液中加入动物或植物脂肪以及甘氨酸、丝氨酸或苯丙氨酸中的至少一种氨基酸或尿素，乳液的稳定性将提高到可以通过高压灭菌消毒的程度，并具有营养特性。本发明还涉及以上述方式稳定乳剂的制备。
• Concentrated stable fluorchemical aqueous emulsions
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0282949A2

  公开（公告）日：1988-09-21

  A stable concentrated aqueous emulsion of perfluorochemical, a phos­pholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include addition emulsifiers of SURFYNOL®SE surfactant and PLURONIC® P-105 surfactant. The emulsion is produced using an improved emul­sification technique.

  一种由全氟化学品、磷脂和脂肪酸甘油三酯组成的稳定浓缩水乳液已经得到证实，它具有更高的稳定性、更小的粒径和更强的生物系统耐受性。这种乳液可用作氧气运输介质，如人造血液。乳液中还可添加 SURFYNOL®SE 表面活性剂和 PLURONIC® P-105 表面活性剂等乳化剂。该乳液采用改进的乳化技术制成。
• Process for rapid thawing and storage of frozen fluorocarbon emulsion, and resultant product
  申请人：ALPHA THERAPEUTIC CORPORATION

  公开号：EP0548601A1

  公开（公告）日：1993-06-30

  A method for rapidly preparing a frozen fluorocarbon emulsion for administration without degradation and having an extended shelf life is disclosed.

  本发明公开了一种快速制备冷冻碳氟化合物乳剂的方法，该乳剂可在不降解的情况下给药，并具有较长的保质期。