A decarboxylative approach for regioselective hydroarylation of alkynes
作者:Jing Zhang、Ruja Shrestha、John F. Hartwig、Pinjing Zhao
DOI:10.1038/nchem.2602
日期:2016.12
group that activates one of several aromatic C–H bonds. Here we report a new catalytic method for regioselective alkyne hydroarylation with benzoicacid derivatives during which the carboxylate functionality directs the alkyne to the ortho-C–H bond with elimination in situ to form a vinylarene product. The decarboxylation stage of this tandem sequence is envisioned to proceed with the assistance of
Regioselective C−H Hydroarylation of Internal Alkynes with Arenecarboxylates: Carboxylates as Deciduous Directing Groups
作者:Liangbin Huang、Agostino Biafora、Guodong Zhang、Valentina Bragoni、Lukas J. Gooßen
DOI:10.1002/anie.201600894
日期:2016.6.6
catalytic [Ru(p‐cym)I2]2 and the base guanidine carbonate, benzoic acids react with internalalkynes to give the corresponding 2‐vinylbenzoic acids. This alkyne hydroarylation is generally applicable to diversely substituted electron‐rich and electron‐poor benzoic and acrylic acids. Aryl(alkyl)acetylenes react regioselectively with formation of the alkyl‐branched hydroarylation products, and propargylic
Palladium-catalyzed double arylations of terminal olefins in acetic acid
作者:Daichao Xu、Chunxin Lu、Wanzhi Chen
DOI:10.1016/j.tet.2011.12.017
日期:2012.2
A palladium-catalyzed Heck diarylation of terminalolefins under ligand-free conditions in acetic acid is described. This procedure allows double arylation of terminalolefins affording trisubstituted olefins in good to excellent yields. The methodology is applicable to the coupling of both electron-deficient and electron-rich aryl iodides leading to symmetrical and unsymmetrical β,β-diarylated alkenes
The rhodium(I)-catalyzed reaction of alkynes with arylboronic acids in the presence of formaldehyde resulted in a carbon monoxide gas-free carbonylative arylation to yield α,β-enones. The simultaneous loading of phosphine-ligated and phosphine-free rhodium(I) complexes is required for efficient catalysis, which catalyze the abstraction of a carbonyl moiety from formaldehyde (decarbonylation) and its
Palladium-catalyzed hydroarylation of alkynes with arylboronic acids
作者:Xiaoling Xu、Jiuxi Chen、Wenxia Gao、Huayue Wu、Jinchang Ding、Weike Su
DOI:10.1016/j.tet.2010.01.086
日期:2010.3
Reaction of symmetrical and unsymmetrical alkynes with arylboronicacids, using PdCl2 as catalyst source and i-Pr2NPPh2 as ligand, afforded trisubstituted alkenes with regioselectivity in good to excellent yields without a common additional acetic acid. Its efficiency has been demonstrated by its good functional groups, high yield and crowded substrates.