6-(naphthalen-1-yl)-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(naphthalen-1-yl)-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione
• 英文别名: 6-naphthalen-1-yl-6aH-isoindolo[2,3-a]quinazoline-5,11-dione
• 化学式: C₂₅H₁₆N₂O₂
• 分子量: 376.414
• InChiKey: JQSXZCKCNWDEPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  靛红酸酐 、 1-萘胺 、 邻羧基苯甲醛 在 β-环糊精 作用下， 以 水 为溶剂， 反应 0.17h， 以75%的产率得到6-(naphthalen-1-yl)-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione
  参考文献：
  名称：

  β-Cyclodextrin mediated MCR in water: synthesis of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives under microwave irradiation

  摘要：

  We report a faster and greener approach for the synthesis of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives of potential pharmacological interest via a beta-CD mediated MCR in water under microwave irradiation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.09.138

文献信息

• Metal–Catalyst-Free Green and efficient synthesis of five and six membered fused N-heterocyclic quinazoline derivatives
  作者：M.V. Madhubabu、R. Shankar、G. Rajeshwar Reddy、T. Srinivasa Rao、Mandava V. Basaveswara Rao、Raghunadh Akula

  DOI：10.1016/j.tetlet.2016.09.094

  日期：2016.11

  An efficient and green approach has been developed for the construction of Tetracyclic nitrogen-bridgehead compounds were designed and synthesized in good yields. The reaction of easily prepared 3-bromoisobenzofuran-1(3H)-one with isatoic anhydride and amines gave the desired isoindoloquinazolinone derivatives in moderate to good yields. It is also amenable for scale-up. (C) 2016 Elsevier Ltd. All rights reserved.
• β-Cyclodextrin mediated MCR in water: synthesis of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives under microwave irradiation
  作者：G. Rajeshwar Reddy、T. Ram Reddy、R. Gangadhara Chary、Suju C. Joseph、Soumita Mukherjee、Manojit Pal

  DOI：10.1016/j.tetlet.2013.09.138

  日期：2013.12

  We report a faster and greener approach for the synthesis of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives of potential pharmacological interest via a beta-CD mediated MCR in water under microwave irradiation. (C) 2013 Elsevier Ltd. All rights reserved.