(4-bromo-benzyl)-[1]naphthyl-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-bromo-benzyl)-[1]naphthyl-amine
• 英文别名: (4-Brom-benzyl)-[1]naphthyl-amin；N-[(4-bromophenyl)methyl]naphthalen-1-amine
• 化学式: C₁₇H₁₄BrN
• 分子量: 312.209
• InChiKey: NJEKTSBHFMBECP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-bromo-benzyl)-[1]naphthyl-amine 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and in vitro activity of new tetrahydronaphtho[1,2-b]azepine derivatives against Trypanosoma cruzi and Leishmania chagasi parasites

  摘要：

  Series of 2-exo-aryl-1,4-epoxy-2,3,4,5-tetrahydronaphtho[1,2-b]azepines 3a-k and cis-2-aryl-4-hydroxy2,3,4,5-tetrahydronaphtho[1,2-b] azepines 4a-j were synthesized and evaluated against free and intracellular live forms of Trypanosoma cruzi and Leishmania chagasi parasites using in vitro assays. Cell toxicity was also analyzed on Vero and THP-1 mammalian cell lines. The compounds 3c, 3f, and 4d were the most active against both live forms of T. cruzi parasites with low mammalian cell toxicity. Some compounds were active on free live forms of L. chagasi parasites but none was active on intracellular amastigotes of L. chagasi infecting THP-1 macrophages. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.013
• 作为产物：
  描述：

  对溴甲苯 在 四氯化碳 、 乙醇 、 溴 作用下， 生成 (4-bromo-benzyl)-[1]naphthyl-amine
  参考文献：
  名称：

  Halogenated Benzophenoxazine Dyes

  摘要：

  DOI：

  10.1021/ja01178a025

文献信息

• Catalyst-free Alkylation of Aromatic Amines with Aldehydes
  作者：Qi He、Zhouyu Wang、Shan Qian、Zhenju Jiang、Jianhui Li、Dehong Jiang、Wensi Ai

  DOI：10.2174/1570178611310050012

  日期：2013.5.1

  In the absence of any additional catalysts, a series of aromatic amines were alkylated with a range of aromatic and aliphatic aldehydes. Moderate to excellent isolated yields (up to 94%) were obtained under mild conditions. Simultaneously, the reaction time dramatically shortened from hours to minutes when the Microwave technique was used.

  在没有任何额外催化剂的情况下，一系列芳香胺与多种芳香和脂肪醛进行了烷基化反应。在温和条件下获得了中等到优异的分离产率（最高可达94%）。与此同时，当使用微波技术时，反应时间从几个小时缩短到了几分钟。