1-(naphthalen-2-yl)-1H-tetrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(naphthalen-2-yl)-1H-tetrazole
• 英文别名: 1-(2-Naphthyl)-1H-tetrazole；1-naphthalen-2-yltetrazole
• 化学式: C₁₁H₈N₄
• mdl: MFCD01469507
• 分子量: 196.211
• InChiKey: UMDOSWJUTAZSCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 sodium nitrite 作用下， 生成 1-(naphthalen-2-yl)-1H-tetrazole
  参考文献：
  名称：

  Pinner, Chemische Berichte, 1897, vol. 30, p. 1885

  摘要：

  DOI：

文献信息

• [3+1+1] type cyclization of ClCF₂COONa for the assembly of imidazoles and tetrazoles <i>via in situ</i> generated isocyanides
  作者：Ya Wang、Yao Zhou、Qiuling Song

  DOI：10.1039/d0cc01919d

  日期：——

  A facile synthesis of imidazoles and tetrazoles via [3+1+1] type cyclization of ClCF2COONa is developed. A diverse array of imidazoles and tetrazoles were obtained in decent yields via isocyanide intermediates. Notably, this is the first example of the cycloaddition of in situ generated isocyanides.

  通过ClCF 2 COONa的[3 + 1 + 1]型环化，可轻松合成咪唑和四唑。通过异氰酸酯中间体以适当的产率获得了各种各样的咪唑和四唑。值得注意的是，这是就地生成的异氰酸酯环加成的第一个例子。
• SiO₂–H₃BO₃promoted solvent-free, green and sustainable synthesis of bioactive 1-substituted-1H-tetrazole analogues
  作者：Mehtab Parveen、Faheem Ahmad、Ali Mohammed Malla、Shaista Azaz

  DOI：10.1039/c4nj02079k

  日期：——

  1-substituted-1H-tetrazole analogues 4(a–o) were synthesized, which were typically accessed via a facile, solvent-free and green synthetic protocol. The reaction involves expeditious reusable catalyst (SiO2–H3BO3) promoted condensation between a variety of heterocyclic/aromatic amines, sodium azide and triethyl ortho-formate, eliminating the use of an environmentally toxic solvent. This new eco-friendly and sustainable

  在本研究中，合成了多功能的1-取代-1 H-四唑类似物4（a-o）的聚焦库，通常可通过便捷，无溶剂和绿色的合成方案进行访问。该反应涉及快速重复使用的催化剂（SiO 2 -H 3 BO 3），促进了各种杂环/芳族胺，叠氮化钠和邻位三乙基之间的缩合-甲酸盐，无需使用对环境有毒的溶剂。这种新的生态友好和可持续的方案以高纯度显着提高了合成效率（90-97％，收率）。这种二氧化硅-硼酸催化剂是空气和水稳定的，易于用廉价的二氧化硅和硼酸制备。本方法是一种绿色方案，具有几个优点，例如，产品收率高，操作程序简单，化学废物的产生最少，温和的反应条件，较短的反应曲线，催化剂的制备容易以及可循环使用多达五个周期没有明显的催化活性损失。在本研究中达到的优化条件表明，2.5 mol％的SiO 2 -H 3 BO在90°C下无溶剂条件下的3催化剂是以优异的产率合成四唑衍生物的最合适条件。本协议适用于更广泛的衬底范围（富电子和缺电子）。具有烟酸核（
• Synthesis and characterisation of tetrazole compounds: 3 series of new ligands representing versatile building blocks for iron(II) spin-crossover compounds
  作者：C. Matthias Grunert、Peter Weinberger、Johannes Schweifer、Christina Hampel、Arno F. Stassen、Kurt Mereiter、Wolfgang Linert

  DOI：10.1016/j.molstruc.2004.07.036

  日期：2005.1

  New tetrazole compounds were synthesized and characterised by NMR and FTIR spectroscopy as well as by single crystal X-ray diffraction. We present in this paper mono- and ditetrazoles, which represent a versatile class of building blocks for the formation of mononuclear iron(H) complexes with monotetrazoles as terminal ligands as well as iron(H) coordination polymers with ditetrazoles as bridging ligands. Especially, the series of alpha,w-bis[tetrazol-1-yl]-alkanes open the field of fascinating supramolecular structures with spin transition properties. (C) 2004 Elsevier B.V. All rights reserved.
• [EN] SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY<br/>[FR] MODULATEURS À PETITES MOLÉCULES DE L'ACTIVITÉ DU FACTEUR DE CROISSANCE (FACTEUR DE DISPERSION) DES HÉPATOCYTES
  申请人：ANGION BIOMEDICA CORP

  公开号：WO2010068287A2

  公开（公告）日：2010-06-17

  The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role.
• Pinner, Chemische Berichte, 1897, vol. 30, p. 1885
  作者：Pinner

  DOI：——

  日期：——