1.4-Diamino-cyclooctan

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1.4-Diamino-cyclooctan
• 英文别名: Cyclooctane-1,4-diamine
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: YCBHOWZVAZUYCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-二硝基苯甲酸 、 1.4-Diamino-cyclooctan 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 N-(4-aminocyclooctyl)-3,5-dinitrobenzamide
  参考文献：
  名称：

  N-（4-氨基环辛基）-3，5-二硝基苯甲酰胺的分离和生物学评估，N-（4-氨基环辛基）-3，5-二硝基苯甲酰胺是一种与Mangrove相关的放线菌假内膜假单胞菌VUK-10的新的半合成衍生物。

  摘要：

  本研究旨在从从红树林生境中分离的放线菌物种中分离出新型生物活性化合物。与此相关，使用稀释板技术分离了内生假性心动过速（VUK-10），并检查了其次生代谢产物谱。经过连续纯化和光谱表征后，即FTIR，质谱，NMR，DEPT，HMQC，HMBC和COZY光谱学，鉴定出两种化合物，包括半合成衍生物N-（4-氨基环辛基）-3、5-二硝基苯甲酰胺（1）得自新型天然产物环辛烷-1,4-二胺（3）的前体，以及已知的化合物3-（（（1H-吲哚-6-基）甲基）六氢吡咯并[1，2-a]吡嗪-1 ，4-二酮（2）。表征的化合物对体外癌细胞系MDA-MB-231，OAW-42，HeLa，MCF-7和MCF-7显示，HELA细胞最易感（IC50-10 nM化合物1和2），其次是其他研究的细胞。另一方面，所研究化合物对被测病原体的抗菌和抗真菌活性表明，所有被测细菌和真菌种类均具有显着的抗菌活性。此外，对于白色念珠菌，

  DOI：

  10.1007/s13205-016-0472-0

文献信息

• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS
  申请人：Peretolchin Maxim

  公开号：US20120252987A1

  公开（公告）日：2012-10-04

  The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

  本发明涉及一种通过将三聚氰胺和至少一种具有至少两个主要氨基的不同氨基的三聚氰胺衍生物以及可能还包括尿素和/或至少一种尿素衍生物和/或至少一种至少双官能团二异氰酸酯或多异氰酸酯和/或至少一种至少具有两个羧基的羧酸或其衍生物缩合，从而制备含有两性功能化的高支化三聚氰胺-多胺聚合物的方法。可选地，对所获得的聚合物的部分氨基进行季铵化，然后将所获得的聚合物与至少一种能够与氨基发生缩合或加成反应的化合物反应，并可选地对第一步中获得的聚合物的部分氨基进行季铵化。本发明还涉及通过本发明的方法可以获得的含有两性功能化的高支化三聚氰胺-多胺聚合物，以及将其用作表面活性剂的用途。
• Dendrimers as Molecular Translocators
  申请人：Goodman Murray

  公开号：US20080221020A1

  公开（公告）日：2008-09-11

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  运输分子包括一个树状分子和一个生物活性分子。这种运输分子的树状分子包括至少一个鸟氨酸基团，至少一个质子化的鸟氨酸基团，至少一个保护的鸟氨酸基团，至少一个酰胺基团，至少一个质子化的酰胺基团，至少一个保护的酰胺基团，至少一个尿素基团，至少一个质子化的尿素基团，至少一个保护的尿素基团，至少一个硫脲基团，至少一个质子化的硫脲基团，或者至少一个保护的硫脲基团。生物活性分子与树状分子结合。一种增加药物生物利用度的方法包括将药物与本发明的树状分子结合。
• ADHESIVE RESIN, METHOD OF BONDING, AND LAYERED PRODUCT
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1195387A1

  公开（公告）日：2002-04-10

  An adhesive resin obtained by reacting a polyolefin resin (A) having carboxyl groups and/or groups derived therefrom with an amino compound having at least two amino groups, the said adhesive resin being superior in the ability for adhering onto various fluororesins (C) and capable of providing easily laminated products superior in resistance to chemicals and in barriering ability.

  将具有羧基和/或衍生基团的聚烯烃树脂（A）与具有至少两个氨基的氨基化合物反应而得到的粘合剂树脂，该粘合剂树脂在粘合各种氟树脂（C）方面的能力更强，并能提供抗化学性和阻隔能力更强的易层压产品。
• Compositions containing polymeric, ionic compounds comprising imidazolium groups
  申请人：Konradi Rupert

  公开号：US10016354B2

  公开（公告）日：2018-07-10

  The present invention relates to compositions containing polymeric, ionic compounds comprising imidazolium groups. In particular, it relates to the use of polymeric, ionic compounds comprising imidazolium groups in personal care compositions and/or in biocide compositions.

  本发明涉及含有咪唑基团的聚合物离子化合物的组合物。本发明尤其涉及含咪唑基团的聚合物离子化合物在个人护理组合物和/或杀菌剂组合物中的用途。