3,6-bis-(dimethylamino)-xanthene-9-propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,6-bis-(dimethylamino)-xanthene-9-propionic acid
• 英文别名: 3-[3,6-bis(dimethylamino)-9H-xanthen-9-yl]propanoic acid
• 化学式: C₂₀H₂₄N₂O₃
• 分子量: 340.422
• InChiKey: KNSVCGJMAGWLJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  53
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 3,6-bis-(dimethylamino)-xanthene-9-propionic acid 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 氯仿 为溶剂， 生成 C₂₄H₂₇N₃O₅
  参考文献：
  名称：

  Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses

  摘要：

  这项发明提供了用于标记试剂、标记靶物和制备标记试剂的过程。这些标记试剂可以采用青霉素染料、黄色素染料、卟啉染料、香豆素染料或复合染料的形式。这些标记试剂对于标记探针或靶物（包括核酸和蛋白质）非常有用。这些试剂可以被有益地应用于基于蛋白质和核酸探针的分析。它们也适用于实时检测过程。

  公开号：

  US20030225247A1
• 作为产物：
  描述：

  丁二酸酐 、 3-羟基-N,N-二甲基苯胺 反应 1.5h， 生成 3,6-bis-(dimethylamino)-xanthene-9-propionic acid
  参考文献：
  名称：

  Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses

  摘要：

  这项发明提供了用于标记试剂、标记靶物和制备标记试剂的过程。这些标记试剂可以采用青霉素染料、黄色素染料、卟啉染料、香豆素染料或复合染料的形式。这些标记试剂对于标记探针或靶物（包括核酸和蛋白质）非常有用。这些试剂可以被有益地应用于基于蛋白质和核酸探针的分析。它们也适用于实时检测过程。

  公开号：

  US20030225247A1

文献信息

• Real-time nucleic acid detection processes and compositions
  申请人：Rabbani Elazar

  公开号：US20050137388A1

  公开（公告）日：2005-06-23

  This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.

  该发明提供了用于实时核酸检测过程的组合物。这样的实时核酸检测过程是通过将能量转移元素连接到核酸引物、核苷酸、核酸探针或核酸结合剂上进行的。实时核酸检测允许在样品中定性或定量检测或确定感兴趣的单链或双链核酸。该发明还提供了其他过程，包括用于从分析物或分析物库中去除同源多聚序列（例如聚A序列或尾部）的过程。还描述和提供了用于执行这种去除过程的组合物。
• Labeling reagents and labeled tabeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
  申请人：Enzo Life Sciences, Inc.

  公开号：EP1348713A2

  公开（公告）日：2003-10-01

  This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.

  本发明提供了标记试剂、标记靶标和制备标记试剂的工艺。标记试剂可以是氰基染料、呫吨染料、卟啉染料、香豆素染料或复合染料。这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。这些试剂可用于基于蛋白质和核酸探针的检测。它们也适用于实时检测过程。
• Processes for quantitative or qualitative detection of single-stranded or double-stranded nucleic acids
  申请人：Enzo Life Sciences, Inc.

  公开号：US10144956B2

  公开（公告）日：2018-12-04

  This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.

  本发明提供了用于实时核酸检测过程的组合物。这种实时核酸检测过程是利用附着在核酸引物、核苷酸、核酸探针或核酸结合剂上的能量转移元件进行的。实时核酸检测可定性或定量检测或确定样品中感兴趣的单链或双链核酸。本发明还提供了其他工艺，包括从分析物或分析物文库中去除部分均聚序列（如聚 A 序列或尾部）的工艺。本发明还描述并提供了用于执行此类去除过程的组合物。
• Optimized real time nucleic acid detection processes
  申请人：Enzo Life Sciences, Inc.

  公开号：US10144957B2

  公开（公告）日：2018-12-04

  This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided. Paneling and multiplex analyses of more than one nucleic acid analyte using one sample are also provided.

  本发明提供了用于实时核酸检测过程的组合物。这种实时核酸检测过程是利用附着在核酸引物、核苷酸、核酸探针或核酸结合剂上的能量转移元件进行的。实时核酸检测可定性或定量检测或确定样品中感兴趣的单链或双链核酸。本发明还提供了其他工艺，包括从分析物或分析物文库中去除部分均聚序列（如聚 A 序列或尾部）的工艺。本发明还描述并提供了用于执行此类去除过程的组合物。本发明还提供了使用一个样品对一种以上核酸分析物进行分层和多重分析的方法。
• Process for detecting the presence or quantity of enzymatic activity in a sample
  申请人：Enzo Life Sciences, Inc.

  公开号：US20040176586A1

  公开（公告）日：2004-09-09

  This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.

  本发明提供了标记试剂、标记靶标和制备标记试剂的工艺。标记试剂可以是氰基染料、呫吨染料、卟啉染料、香豆素染料或复合染料。这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。这些试剂可用于基于蛋白质和核酸探针的检测。它们也适用于实时检测过程。