化合物RP-54745 | 135330-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 中文名称: 化合物RP-54745
• 英文名称: 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
• 英文别名: 4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one
• CAS: 135330-08-4
• 化学式: C₁₃H₁₂ClNOS₂
• 分子量: 297.8
• InChiKey: BEJJGVDFQORITE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SUTURES AND ANTI-SCARRING AGENTS
  申请人：Angiotech Pharmaceuticals, Inc.

  公开号：EP1978930A2

  公开（公告）日：2008-10-15
• electrical devices, anti-scarring agents, and therapeutic compositions
  申请人：Hunter William L.

  公开号：US20090280153A1

  公开（公告）日：2009-11-12

  Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal.
• Small molecule immunopotentiators and assays for their detection
  申请人：Valiante Nicholas

  公开号：US20110104186A1

  公开（公告）日：2011-05-05

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
• NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS
  申请人：Chen Chien-Hung

  公开号：US20120183600A1

  公开（公告）日：2012-07-19

  The invention relates to a composition that includes a first agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5′-monophosphate-activated protein kinase (AMPK) activator; a second agent that possesses anti-inflammatory activity; and a third agent that possesses serotonin activity.
• [EN] ELECTRICAL DEVICES, ANTI-SCARRING AGENTS, AND THERAPEUTIC COMPOSITIONS<br/>[FR] DISPOSITIFS ELECTRIQUES, AGENTS PREVENANT LA FORMATION DE CICATRICES ET COMPOSITIONS THERAPEUTIQUES
  申请人：ANGIOTECH INT AG

  公开号：WO2006121518A2

  公开（公告）日：2006-11-16

  [EN] Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the devices are implanted within an animal
  [FR] L'invention a pour objet des dispositifs électriques (p. ex. des dispositifs neurostimulateurs et régulateurs du rythme cardiaque) destinés à être mis en contact avec des tissus et qui sont utilisés en combinaison avec un agent empêchant la formation de cicatrices susceptibles de se développer lorsque les dispositifs sont implantés dans un animal.