5-(3,4-dimethoxyphenyl)-5-methyl-3-(1-naphthyl)-4,5-dihydro-1,2-oxazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(3,4-dimethoxyphenyl)-5-methyl-3-(1-naphthyl)-4,5-dihydro-1,2-oxazole
• 英文别名: 5-(3,4-dimethoxyphenyl)-5-methyl-3-naphthalen-1-yl-4H-1,2-oxazole
• 化学式: C₂₂H₂₁NO₃
• 分子量: 347.414
• InChiKey: XMUAWBHYMPMGAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  40
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(1-萘)-乙酮肟 、 3,4-二甲氧基苯乙酮 在 lithium diisopropyl amide 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 以48%的产率得到5-(3,4-dimethoxyphenyl)-5-methyl-3-(1-naphthyl)-4,5-dihydro-1,2-oxazole
  参考文献：
  名称：

  The Preparation of 5-Aryl-5-methyl-4,5-dihydroisoxazoles from Dilithiated C(α), O -Oximes and Select Acetyl Ketones

  摘要：

  Several 5-aryl-5-methyl-4,5-dihydroisoxazoles were prepared by a three-step, one-pot process in 24-83% yield. C(alpha),O-oximes were dilithiated with lithium diisopropylamide and condensed with electron enriched acetophenones, such as 4'-methoxyacetophenone, followed by immediate acid cyclization.

  DOI：

  10.1081/scc-120026359

文献信息

• The Preparation of 5-Aryl-5-methyl-4,5-dihydroisoxazoles from Dilithiated C(α),<b> <i>O</i> </b>-Oximes and Select Acetyl Ketones
  作者：Matthew J. Walters、S. Patrick Dunn、Emily Choi、Amanda N. D'Elia、Morgan E. Warner、Charles F. Beam

  DOI：10.1081/scc-120026359

  日期：2003.12.1

  Several 5-aryl-5-methyl-4,5-dihydroisoxazoles were prepared by a three-step, one-pot process in 24-83% yield. C(alpha),O-oximes were dilithiated with lithium diisopropylamide and condensed with electron enriched acetophenones, such as 4'-methoxyacetophenone, followed by immediate acid cyclization.