5-Acetyl-5-methyl-1,3-dioxan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 5-Acetyl-5-methyl-1,3-dioxan-2-one
• 化学式: C₇H₁₀O₄
• mdl: MFCD18805624
• 分子量: 158.154
• InChiKey: YCPIZZJIUMYANH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-羟基-3-(羟基甲基)-3-甲基-2-丁酮 、 三光气 在 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 5-Acetyl-5-methyl-1,3-dioxan-2-one
  参考文献：
  名称：

  Cyclic carbonates and their reactions with amines

  摘要：

  六元环碳酸酯（2-氧代-1,3-二氧杂环戊烷）中，酮基或碳氢基氧基团结合到环的5位，已被披露。它们与一次或二次环胺惊人地迅速反应，新产品羟基脲醚可用作反应性稀释剂。

  公开号：

  US06020499A1

文献信息

• CYCLIC CARBONYL COMPOUNDS WITH PENDANT CARBONATE GROUPS, PREPARATIONS THEREOF, AND POLYMERS THEREFROM
  申请人：Fujiwara Masaki

  公开号：US20110269917A1

  公开（公告）日：2011-11-03

  A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

  公开了一种制备含有活性吊挂五氟苯基碳酸酯基团的环状羰基化合物的一锅法。这些环状羰基化合物可以通过环开启方法聚合，形成包含侧链五氟苯基碳酸酯基团的ROP聚合物重复单元。使用适当的亲核试剂，可以在环开启聚合之前或之后，选择性地将吊挂的五氟苯基碳酸酯基团转化为各种其他功能基团。
• POLYMERS BEARING PENDANT PENTAFLUOROPHENYL ESTER GROUPS, AND METHODS OF SYNTHESIS AND FUNCTIONALIZATION THEREOF
  申请人：Fujiwara Masaki

  公开号：US20100305281A1

  公开（公告）日：2010-12-02

  A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

  揭示了一种制备含有活性吊挂五氟苯基酯基团的环状羰基化合物的一锅法。这些环状羰基化合物可以通过环开启方法聚合，形成包含侧链五氟苯基酯基团的ROP聚合物重复单元。使用适当的亲核试剂，吊挂的五氟苯基酯基团可以在环开启聚合之前或之后选择性地转化为各种其他功能基团。
• ANTIBACTERIAL POLYMER, PRODUCTION METHOD THEREFOR, AND USAGE THEREOF
  申请人：NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY

  公开号：US20170202217A1

  公开（公告）日：2017-07-20

  Provided is a polymer material having effective antibacterial properties and having bio adaptability in which cytotoxicity, especially low hemolysis, when used in contact with in vivo tissue and blood is suppressed so as to be low. The polymer is characterized by comprising a main chain and a side chain portion which is linked to the main chain via a linker and which contains at least a structure specified by the following (A) and (B). (A) A structure containing a cationic group and (B) a structure in which expression of bio adaptability is expected.

  提供的是一种具有有效抗菌性能并具有生物适应性的聚合物材料，在与体内组织和血液接触时，细胞毒性，尤其是低溶血性，被抑制至较低水平。该聚合物的特征在于包括一个主链和一个通过连接物连接到主链的侧链部分，该侧链部分至少包含以下（A）和（B）指定的结构。 （A）含有阳离子基团的结构和（B）预期具有生物适应性表达的结构。
• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20180117162A1

  公开（公告）日：2018-05-03

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

  制备了包含以下组成部分的凝胶形成嵌段共聚物：i）主要由二价聚乙二醇链组成的中心亲水性块和ii）通过带有一个或多个氢键形成*—N(H)—*基团连接到中心块的两个外周单碳酸酯或多碳酸酯疏水性块。疏水性块包含一个或多个含维生素的亚单位。这些凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。水凝胶组合物在药物输送的库存注射中具有实用性。与由聚乙二醇制备的类似水凝胶相比，氢键*—N(H)—*基团提供了凝胶在体内降解之前更长的生命周期，以及与水凝胶相比更延长和控制释放速率的疏水性药物。
• CYCLIC CARBONYL MONOMERS FUNCTIONALIZED WITH CARBOHYDRATES, POLYMERS DERIVED THEREFROM, AND METHODS OF PREPARATION THEREOF
  申请人：Dubois Philippe

  公开号：US20100317838A1

  公开（公告）日：2010-12-16

  A cyclic carbonyl monomer has the formula (7): wherein at least one W′ or W a group comprises a protected glycoside; each Z independently represents O, S, NH or NW″; n is an integer from 0 to 6 wherein when n is 0, carbons labeled 4 and 6 are linked together by a single bond; each W′ and W a group independently represents a hydrogen, a halide, an alkyl group comprising 1 to 20 carbons, an ester group comprising 1 to 20 carbons, an amide group, an aryl group comprising 1 to 20 carbons, an alkoxy group comprising 1 to 20 carbons, or a foregoing W′ or W a group substituted with a protected glycoside; and each W″ group independently represents an alkyl group comprising 1 to 20 carbons, an aryl group comprising 1 to 20 carbons, or a foregoing W″ group substituted with a protected glycoside.

  一个环状的羰基单体具有公式（7）：其中至少一个W'或Wagroup包含一个受保护的糖苷；每个Z独立地表示O、S、NH或NW″；n是一个整数，从0到6，当n为0时，标记为4和6的碳通过单键连接在一起；每个W'和Wagroup独立地表示氢、卤素、包含1到20个碳的烷基、包含1到20个碳的酯基、酰胺基、包含1到20个碳的芳基、包含1到20个碳的烷氧基，或用受保护糖苷取代的前述W'或Wagroup；每个W″基独立地表示包含1到20个碳的烷基、包含1到20个碳的芳基，或用受保护糖苷取代的前述W″基。