N-methyl-N-phenethylpyridin-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-methyl-N-phenethylpyridin-2-amine
• 英文别名: N-methyl-N-(2-phenylethyl)pyridin-2-amine
• 化学式: C₁₄H₁₆N₂
• 分子量: 212.294
• InChiKey: HLOOVIMCOVBZBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氟吡啶 、 n-甲基苯基乙胺 在 bis(1,5-cyclooctadiene)nickel (0) 、 sodium t-butanolate 、 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以98%的产率得到N-methyl-N-phenethylpyridin-2-amine
  参考文献：
  名称：

  镍催化的氟代芳烃和胺的偶联

  摘要：

  AbstractThe combination of bis(cyclooctadiene)nickel [Ni(COD)2] and 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene hydrochloride (IPr⋅HCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert‐butoxide (t‐BuONa). Activated, unactivated and deactivated fluoroarenes as well as fluoropyridines can react with cyclic or acyclic aliphatic amines. The reactions tolerate various functional groups in the fluorides including PhC(O), C(O)NEt2, CF3, OMe and vinyl groups.magnified image

  DOI：

  10.1002/adsc.201300485

文献信息

• Nickel‐Catalyzed Coupling of Fluoroarenes and Amines
  作者：Feng Zhu、Zhong‐Xia Wang

  DOI：10.1002/adsc.201300485

  日期：2013.12.16

  AbstractThe combination of bis(cyclooctadiene)nickel [Ni(COD)2] and 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene hydrochloride (IPr⋅HCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert‐butoxide (t‐BuONa). Activated, unactivated and deactivated fluoroarenes as well as fluoropyridines can react with cyclic or acyclic aliphatic amines. The reactions tolerate various functional groups in the fluorides including PhC(O), C(O)NEt2, CF3, OMe and vinyl groups.magnified image