pinacolone-N,N-dimethylhydrazone | 69498-77-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: pinacolone-N,N-dimethylhydrazone
• 英文别名: methyl-t-butylketone N,N-dimethylhydrazone；2-(3,3-Dimethylbutan-2-ylidene)-1,1-dimethylhydrazine；N-(3,3-dimethylbutan-2-ylideneamino)-N-methylmethanamine
• CAS: 69498-77-7
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: JRFUDCODMQUENM-UHFFFAOYSA-N

物化性质

• 沸点：
  171.3±23.0 °C(Predicted)
• 密度：
  0.80±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  pinacolone-N,N-dimethylhydrazone 在 3-苄基羟乙基甲基噻唑氯化锂 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以94%的产率得到频哪酮
  参考文献：
  名称：

  Balram; Ram; Sai Prakash, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 8, p. 626 - 627

  摘要：

  DOI：

文献信息

• Transition-metal–carbon bonds. Part 45. Attempts to cyclopalladate some aliphatic oximes, NN-dimethylhydrazones, ketazines, and oxime O-allyl ethers. Crystal structures of [Pd₂{CH₂C(CH₃)₂C(NOH)CH₃}₂Cl₂] and [Pd{CH₂C(NNMe₂)C(CH₃)₃}(acac)]
  作者：Anthony G. Constable、Walter S. McDonald、Lynne C. Sawkins、Bernard L. Shaw

  DOI：10.1039/dt9800001992

  日期：——

  PMe2Ph, PPh3, or pyridine). The salts [Pd(CH2C(CH3)2C(NOH)CH3}(Ph2PCH2CH2PPh2)](X = l or BPh4) have also been prepared. E-Ethyl t-butyl and E-phenyl t-butyl ketoximes are similarly cyclopalladated, but oximes of other carbonyl compounds, e.g. trimethylacetaldehyde, methyl isopropyl ketone, di-isopropyl ketone, ethyl methyl ketone, or 2-methylcyclohexanone, give dark intractable products. In contrast, methyl

  E-甲基叔丁基酮肟，与乙酸钠和Na 2 [PdCl 4 ]在甲醇中的环钯在叔丁基甲基上区域特异性地反应，得到氯桥联的配合物[Pd 2 CH 2 C（CH 3）2 C（NOH）CH 3 } 2 Cl 2 ]（1a），已经确定了其晶体结构（参见下文）。制备了相应的溴化物和碘化物配合物，以及通过桥裂反应制备的几种单核物质，例如[[图] OH] CH 3 } X（L）]（X = Cl或Br; L = CO， PMe 2 Ph，PPh 3，或吡啶）。盐[加入Pd（CH 2 C（CH 3）2 C（NOH）CH 3 }（PH 2 PCH 2 CH 2 PPH 2）]（X = 1或BPH 4）也被制备。Ë乙基叔丁基类似地，环戊二烯酮和E-苯基叔丁基酮肟具有类似的环palpalpalated，但其他羰基化合物的肟，例如三甲基乙醛，甲基异丙基酮，二异丙基酮，乙基甲基酮或2-甲基环己酮，则可得到深色难处理的产物。丁基NN-二甲基hydr与Na
• FERROUS SULFATE PROMOTED CONVERSION OF<i>N,N</i>-DIMETHYLHYDRAZONES AND PHENYLHYDRAZONES TO CARBONYL COMPOUNDS
  作者：Aayesha Nasreen、Srinivas R. Adapa

  DOI：10.1080/00304949909355344

  日期：1999.10
• Galli, Beatrice; Gasparrini, Francesco; Maresca, Luciana, Journal of the Chemical Society, Dalton Transactions, 1983, p. 1483 - 1488
  作者：Galli, Beatrice、Gasparrini, Francesco、Maresca, Luciana、Natile, Giovanni、Palmieri, Gianni

  DOI：——

  日期：——
• Synthesis, reactivity and characterization of cyclometallated palladium(II) compounds derived from pinacolone-N,N-dimethylhydrazone
  作者：José M Vila、Margarita López-Torres、Alberto Fernández、M.Teresa Pereira、Juna M Ortigueira、Jesús J Fernández

  DOI：10.1016/s0020-1693(02)01146-5

  日期：2003.1

  Pinacolone-N,N-dimethylhydrazone was regiospecifically cyclopalladated by Pd(OAc)(2) in glacial acetic acid on the -C(Me)=N-methyl group to give the acetato-bridged complex [PdCH2C(CMe3)=NNMe2}(mu-O2CMe)](2) (1). Subsequent treatment with aqueous sodium chloride or bromide gave the corresponding halide-bridged complexes [Pd CH2C(CMe3) =NNMe2} (mu-X)](2) (2, X = Cl; 3, X = Br). Treatment of 2 and 3 with tertiary diphosphines in a 1: 1 molar ratio yielded the dinuclear complexes [Pd[CH2C(CMe3)=NNMe2](X)}(2)mu-Ph2PRPPh2}] (4, 5, R = CH2; 6, 7, R = CHMe; 8, 9, R = CCH2; 10, 11, R = NMe; 12, 13, R = trans-CHCH, 14, 15, R = C2H4, 16, 17, R = C3H6; 18, 19, R = C4H8). Treatment of 2 and 3 with AgClO4 and the appropriate diphosphine ligand in a 1:2 molar ratio, afforded the mononuclear species [PdCH2C(CMe3)=NNMe2)(Ph2PRPPh2-P,P')][ClO4]}] (20, R = CH2; 21, R = CHMe; 22, R = CCH2; 23, R = NMe; 24, R = cis-CHCH, 25, R = C2H2, 26, R = C3H6; 27, R = C4H8). The complexes were characterized by elemental analysis (C, H, N), conductivity measurements, IR and H-1 and (31)p H-1} NMR spectroscopy, and by mass spectrometry. (C) 2002 Elsevier Science B.V. All rights reserved.
• Balram; Ram; Sai Prakash, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 8, p. 626 - 627
  作者：Balram、Ram、Sai Prakash

  DOI：——

  日期：——