申请人:WARNER-LAMBERT COMPANY
公开号:EP0075442A1
公开(公告)日:1983-03-30
There is disclosed a process for producing benzoyl peroxide in crystalline form with crystals having a size of up to approximately 10 microns, comprising:
forming a first solution comprising benzoyl peroxide and a precipitate-promoting material selected from sulphur-containing aliphatic ethers, long-chain aliphatic and araliphatic ethers, ethylene oxide derivatives, and mixtures thereof;
mixing the first solution with a second solution comprising an aqueous solution of a non-toxic and non-reactive dispersant selected from cellulosic derivatives, anionic surfactants, non-ionic surfactants, inorganic colloidal materials, and mixtures thereof; and
recovering the benzoyl peroxide in the desired crystalline form.
The process may be performed at room temperature and is therefore safe and energy conservative. The resulting benzoyl peroxide crystals are of desirable small size, and are particularly well suited for incorporation into commercial cosmetic and pharmaceutical preparations.
本发明公开了一种生产结晶状过氧化苯甲酰的工艺,其结晶的尺寸可达约 10 微米,该工艺包括
形成由过氧化苯甲酰和沉淀促进材料组成的第一溶液,沉淀促进材料选自含硫脂肪族醚、长链脂肪族和芳香族醚、环氧乙烷衍生物及其混合物;
将第一种溶液与第二种溶液混合,第二种溶液包含一种无毒、无反应的分散剂水溶液,该分散剂选自纤维素衍生物、阴离子表面活性剂、非离子表面活性剂、无机胶体材料及其混合物;以及
回收所需晶型的过氧化苯甲酰。
该工艺可在室温下进行,因此既安全又节能。所得到的过氧化苯甲酰晶体具有理想的小尺寸,特别适合加入商业化妆品和药物制剂中。