(Z)-2-(4-methoxyphenyl)-1-(4-methylsulfanyl-phenyl)-1-ethenyl 2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-2-(4-methoxyphenyl)-1-(4-methylsulfanyl-phenyl)-1-ethenyl 2,2,2-trifluoroacetate
• 英文别名: [(Z)-2-(4-methoxyphenyl)-1-(4-methylsulfanylphenyl)ethenyl] 2,2,2-trifluoroacetate
• 化学式: C₁₈H₁₅F₃O₃S
• 分子量: 368.377
• InChiKey: JBWCHDLHQLFUFO-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对甲氧基苯乙酸 、 茴香硫醚 、 三氟乙酸酐 在 磷酸 、 三氟乙酸酐 作用下， 以 水 为溶剂， 反应 0.01h， 以60%的产率得到(Z)-2-(4-methoxyphenyl)-1-(4-methylsulfanyl-phenyl)-1-ethenyl 2,2,2-trifluoroacetate
  参考文献：
  名称：

  A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C–C bond formation reaction

  摘要：

  In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond formation reaction when reacted with arenes of type II to give 1,2-diaryl-1-ethanones III in good to excellent yield. Under the solvent-free conditions these chemical transformations that normally require longer reaction time can be performed within minutes in good yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00407-1

文献信息

• A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C–C bond formation reaction
  作者：Venugopal Rao Veeramaneni、Manojit Pal、Koteswar Rao Yeleswarapu

  DOI：10.1016/s0040-4020(03)00407-1

  日期：2003.4

  In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond formation reaction when reacted with arenes of type II to give 1,2-diaryl-1-ethanones III in good to excellent yield. Under the solvent-free conditions these chemical transformations that normally require longer reaction time can be performed within minutes in good yield. (C) 2003 Elsevier Science Ltd. All rights reserved.