1-(2-chlorophenyl)-4-phenethylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-chlorophenyl)-4-phenethylpiperazine
• 英文别名: 1-(2-Chlorophenyl)-4-(2-phenylethyl)piperazine
• 化学式: C₁₈H₂₁ClN₂
• 分子量: 300.831
• InChiKey: GPLJHNLLDGQNDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-chlorophenyl)-4-phenethylpiperazine 、 草酸 生成 1-(2-chlorophenyl)-4-phenethylpiperazine oxalate
  参考文献：
  名称：

  Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands

  摘要：

  Selective sigma(2) ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the sigma(2)-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.09.038
• 作为产物：
  描述：

  1-(2-氯苯基)哌嗪 、 乙基溴苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-(2-chlorophenyl)-4-phenethylpiperazine
  参考文献：
  名称：

  Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands

  摘要：

  Selective sigma(2) ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the sigma(2)-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.09.038

文献信息

• Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands
  作者：William C. Motel、Jason R. Healy、Eddy Viard、Buddy Pouw、Kelly E. Martin、Rae R. Matsumoto、Andrew Coop

  DOI：10.1016/j.bmcl.2013.09.038

  日期：2013.12

  Selective sigma(2) ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the sigma(2)-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand. (C) 2013 Elsevier Ltd. All rights reserved.