3-(4-ethoxycarbonylbutyl)-1,1,2-trimethyl-1H-benzo[e]indolium bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(4-ethoxycarbonylbutyl)-1,1,2-trimethyl-1H-benzo[e]indolium bromide
• 英文别名: 3-(4-ethoxycarbonylbutyl)-1,1,2-trimethyl-1H-benz[e]indolenium；Ethyl 5-(1,1,2-trimethylbenzo[e]indol-3-ium-3-yl)pentanoate;bromide
• 化学式: Br*C₂₂H₂₈NO₂
• 分子量: 418.374
• InChiKey: IBBLKRRZXREAKO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-ethoxycarbonylbutyl)-1,1,2-trimethyl-1H-benzo[e]indolium bromide 在 盐酸 、 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 生成 5-(2-((1E,3E,5E,7Z)-7-(3-(4-carboxybutyl)-1,1-dimethyl-1H-benzo[e]indol-2(3H)-ylidene)hepta-1,3,5-trienyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)pentanoate
  参考文献：
  名称：

  Synthesis, fluorescence and biodistribution of a bone-targeted near-infrared conjugate

  摘要：

  Enhanced imaging of early-stage bone abnormalities, such as primary tumors or metastases is highly required as the widely-used bone scan frequently lacks the desired sensitivity. Near IR (NIR) fluorescence imaging affords high contrast and enhanced sensitivity, as body tissue expresses minimal autofluorescence at NIR range (600-1200 nm). Indocyanine green (ICG), a biocompatible NIR dye, is widely used in the imaging of various organs, such as liver, heart and blood circulation. We report the preparation and in-vivo testing of a bone-targeting ICG derivative, in comparison to the parent molecule(s). Since ICG itself is chemically unreactive, and could not form conjugates, we prepared two novel ICG conjugatable derivatives. The overall ICG structure was maintained while only a replacement of one or two sulfonate groups with carboxylic acids resulted in new linkers for covalent binding to biomolecules. These derivatives were evaluated for their fluorescence and biodistribution in comparison to ICG and were found to be comparable. One of the novel ICG-derivatives was conjugated to a bone-targeting moiety and this new compound was found to bind to growing regions of the skeleton, and emit fluorescence for as long as two weeks in young mice. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.08.040
• 作为产物：
  描述：

  1,1,2-三甲基苯-1H-苯并[e]吲哚 、 5-溴戊酸乙酯 反应 1.0h， 以26%的产率得到3-(4-ethoxycarbonylbutyl)-1,1,2-trimethyl-1H-benzo[e]indolium bromide
  参考文献：
  名称：

  Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery

  摘要：

  Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.

  DOI：

  10.1021/jm2001986

文献信息

• Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery
  作者：Heinz Langhals、Ana Varja、Peter Laubichler、Marcus Kernt、Kirsten Eibl、Christos Haritoglou

  DOI：10.1021/jm2001986

  日期：2011.6.9

  Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.
• Synthesis, fluorescence and biodistribution of a bone-targeted near-infrared conjugate
  作者：Dana M. Mizrahi、Ofra Ziv-Polat、Benny Perlstein、Eran Gluz、Shlomo Margel

  DOI：10.1016/j.ejmech.2011.08.040

  日期：2011.10

  Enhanced imaging of early-stage bone abnormalities, such as primary tumors or metastases is highly required as the widely-used bone scan frequently lacks the desired sensitivity. Near IR (NIR) fluorescence imaging affords high contrast and enhanced sensitivity, as body tissue expresses minimal autofluorescence at NIR range (600-1200 nm). Indocyanine green (ICG), a biocompatible NIR dye, is widely used in the imaging of various organs, such as liver, heart and blood circulation. We report the preparation and in-vivo testing of a bone-targeting ICG derivative, in comparison to the parent molecule(s). Since ICG itself is chemically unreactive, and could not form conjugates, we prepared two novel ICG conjugatable derivatives. The overall ICG structure was maintained while only a replacement of one or two sulfonate groups with carboxylic acids resulted in new linkers for covalent binding to biomolecules. These derivatives were evaluated for their fluorescence and biodistribution in comparison to ICG and were found to be comparable. One of the novel ICG-derivatives was conjugated to a bone-targeting moiety and this new compound was found to bind to growing regions of the skeleton, and emit fluorescence for as long as two weeks in young mice. (C) 2011 Elsevier Masson SAS. All rights reserved.