双(1-甲基吡啶-4-氨) | 117927-28-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 双(1-甲基吡啶-4-氨)
• 英文名称: Bis(1-methylpiperidin-4-yl)amine
• 英文别名: 1-methyl-N-(1-methylpiperidin-4-yl)piperidin-4-amine
• CAS: 117927-28-3
• 化学式: C₁₂H₂₅N₃
• mdl: MFCD03426080
• 分子量: 211.351
• InChiKey: LLBSZFPXXCBOFL-UHFFFAOYSA-N

物化性质

• 沸点：
  102-105/0.45mm
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933399090
• 危险类别：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  、 双(1-甲基吡啶-4-氨) 在 palladium diacetate 、 2-(二叔丁基膦)联苯 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 生成 3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)-N-(1-methylpiperidin-4-yl)imidazo[1,2-a]pyridin-7-amine
  参考文献：
  名称：

  Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

  摘要：

  Focussed studies on imidazopyridine inhibitors of Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG) have significantly advanced the series towards desirable in vitro property space. LLE-based approaches towards combining improvements in cell potency, key physicochemical parameters and structural novelty are described, and a structure-based design hypothesis relating to substituent regiochemistry has directed efforts towards key examples with well-balanced potency, ADME and kinase selectivity profiles.

  DOI：

  10.1016/j.bmcl.2019.08.014
• 作为产物：
  描述：

  1-methyl-N-(1-methylpiperidin-4-yl)piperidin-4-imine 以59%的产率得到
  参考文献：
  名称：

  BINIECKI, STANISLAW;LISTOPADZKI, ZBIGNIEW, ACTA POL. PHARM., 44,(1987) N 2, 140-142

  摘要：

  DOI：

文献信息

• PRODUCTION METHOD FOR LITHIUM SULFAMATE, AND NOVEL LITHIUM SULFAMATE
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3778565A1

  公开（公告）日：2021-02-17

  Provided is a method for producing a lithium sulfamate. The method for producing a lithium sulfamate includes (1) reacting a compound (1) represented by the following formula (1): wherein X is fluorine, chlorine, bromine, or iodine, with a compound (2) represented by the following formula (2) : wherein R1 and R2 are each individually a substituent that is: -H; a group represented by the formula: -Op-(SiR32O)n-SiR43 wherein R3 and R4 are each individually an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, an alkenyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, an alkynyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, or an aryl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; n is an integer of 0 or greater; and p is 0 or 1; a C1-C7 alkyl group; a C2-C7 alkenyl group; a C2-C7 alkynyl group; a C6-C15 aryl group; -SO2X1 wherein X1 is -H, -F, or an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; -SO3X2 wherein X2 is -H, -F, or an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; or a C2-C7 hydrocarbon group that forms a cyclic structure by bonding of R1 and R2, in which the cyclic structure optionally contains a multiple bond, the substituent optionally containing at least one bi- to hexavalent heteroatom in the structure and being a substituent in which at least one hydrogen atom is optionally replaced with a fluorine atom or a CO-C7 functional group, to obtain a compound (3) represented by the following formula (3): wherein R1 and R2 are defined as above.

  提供了一种生产氨基磺酸锂的方法。生产氨基磺酸锂的方法包括：（1）使下式（1）代表的化合物（1）反应： 其中 X 是氟、氯、溴或碘，与由下式（2）代表的化合物（2）反应： 其中 R1 和 R2 各自是一个取代基，该取代基是 -H; 由下式代表的基团-Op-(SiR32O)n-SiR43，其中 R3 和 R4 分别是至少一个氢原子可选地被氟原子取代的烷基、至少一个氢原子可选地被氟原子取代的烯基、至少一个氢原子可选地被氟原子取代的炔基或至少一个氢原子可选地被氟原子取代的芳基；n 是 0 或更大的整数；p 是 0 或 1； C1-C7 烷基 C2-C7 烯基 C2-C7炔基 C6-C15 芳基； -SO2X1，其中 X1 为-H、-F 或烷基，其中至少一个氢原子可选择被氟原子取代； -SO3X2，其中 X2 是-H、-F 或至少一个氢原子可选择被氟原子取代的烷基；或 通过 R1 和 R2 键合形成环状结构的 C2-C7 碳氢基团，其中环状结构可选择包含一个多键、 该取代基在结构中可选择含有至少一个双价至六价杂原子，并且是至少一个氢原子可选择被氟原子或 CO-C7 官能基取代的取代基，从而得到下式（3）所代表的化合物（3）： 其中 R1 和 R2 的定义同上。
• ELECTROLYTE SOLUTION, ELECTROCHEMICAL DEVICE, LITHIUM ION SECONDARY BATTERY, MODULE AND COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3761435A1

  公开（公告）日：2021-01-06

  The disclosure provides an electrolyte solution that gives an electrochemical device having low resistance. The electrolyte solution contains a compound represented by the following formula (1). In the formula, R101 and R102 are each individually a substituent such as a C1-C7 alkyl group, the substituent optionally contains at least one divalent to hexavalent hetero atom in a structure or optionally has a structure obtained by replacing at least one hydrogen atom by a fluorine atom or a C0-C7 functional group, and at least one selected from the group consisting of R101 and R102, when both being an alkyl group, contains at least one divalent to hexavalent hetero atom in the structure or has a structure obtained by replacing at least one hydrogen atom by a fluorine atom or a C0-C7 functional group.

  本公开提供了一种电解质溶液，它能使电化学装置具有低电阻。该电解质溶液含有下式（1）所代表的化合物。式中，R101 和 R102 分别是取代基，如 C1-C7 烷基，取代基在结构中任选含有至少一个二价至六价杂原子，或任选具有通过用氟原子或 C0-C7 官能团取代至少一个氢原子而得到的结构、且至少有一个选自 R101 和 R102（当两者均为烷基时）组成的组，在结构上含有至少一个二价至六价杂原子，或具有通过用氟原子或 C0-C7 官能团取代至少一个氢原子而获得的结构。
• ELECTROLYTIC SOLUTION, ELECTROCHEMICAL DEVICE, LITHIUM-ION SECONDARY BATTERY, MODULE AND COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3933999A1

  公开（公告）日：2022-01-05

  Provided are an electrolyte solution and the like that allow an electrochemical device to have low resistance and improved cycle characteristics. The disclosure relates to an electrolyte solution containing at least one compound (1) selected from the group consisting of a compound represented by the following formula (1A) and a compound represented by the following formula (1B): the formula (1A) being: wherein R101 and R102, each independently, are a C5-C10 organic group, optionally contain at least one selected from the group consisting of a hetero atom and an unsaturated bond, and optionally contain a ring, the formula (1B) being: wherein R103 to R105, each independently, are a C1-C10 organic group, optionally contain at least one selected from the group consisting of a hetero atom and an unsaturated bond, and optionally contain a ring.

  本发明提供了一种电解质溶液等，可使电化学装置具有低电阻和更好的循环特性。本公开涉及一种电解质溶液，其中至少含有一种选自下式（1A）和下式（1B）的化合物的化合物（1）： 式（1A）为 其中 R101 和 R102 各自独立地为 C5-C10 有机基团，可选择地含有至少一个选自由杂原子和不饱和键组成的组，并可选择地含有一个环、 式（1B）为 其中 R103 至 R105 各自独立地为 C1-C10 有机基团，可选择地包含至少一个选自杂原子和不饱和键的基团，并可选择地包含一个环。
• COMPOUND, ELECTROLYTIC SOLUTION ADDITIVE, ELECTROLYTIC SOLUTION, ELECTROCHEMICAL DEVICE, LITHIUM ION SECONDARY BATTERY, AND MODULE
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3932928A1

  公开（公告）日：2022-01-05

  Provided are an electrolyte solution and the like that allow an electrochemical device to have low resistance and improved cycle characteristics. The disclosure relates to a compound represented by the following formula (1): wherein R101 to R103, each independently, are a C1-C6 organic group, optionally contain at least one selected from the group consisting of a hetero atom and an unsaturated bond, and are optionally linear, branched, or cyclic.

  本发明提供了一种电解质溶液等，可使电化学装置具有低电阻和更好的循环特性。本公开涉及一种由下式（1）表示的化合物： 其中 R101 至 R103 各自独立地为 C1-C6 有机基团，可选地包含至少一个选自由杂原子和不饱和键组成的组，并且可选地为线性、支链或环状。
• BINIECKI, STANISLAW;LISTOPADZKI, ZBIGNIEW, ACTA POL. PHARM., 44,(1987) N 2, 140-142
  作者：BINIECKI, STANISLAW、LISTOPADZKI, ZBIGNIEW

  DOI：——

  日期：——