(α-bromo-benzyl)-phenyl-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (α-bromo-benzyl)-phenyl-amine
• 英文别名: (α-Brom-benzyl)-phenyl-amin；(α-Brom-benzyl)-anilin；N-[bromo(phenyl)methyl]aniline
• 化学式: C₁₃H₁₂BrN
• 分子量: 262.149
• InChiKey: NNWNCGSNQHBDBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (α-bromo-benzyl)-phenyl-amine 、 furan-2,3,5(4H)-trione pyridine (1:1) 生成 N-苄叉苯胺
  参考文献：
  名称：

  Adams; Vollweiler, Journal of the American Chemical Society, 1918, vol. 40, p. 1740

  摘要：

  DOI：
• 作为产物：
  描述：

  α-Bromobenzyl benzoate 、 苯胺 生成 (α-bromo-benzyl)-phenyl-amine
  参考文献：
  名称：

  Adams; Vollweiler, Journal of the American Chemical Society, 1918, vol. 40, p. 1740

  摘要：

  DOI：

文献信息

• Lactams substituted by cyclic succinates as inhibitors of a beta protein production
  申请人：——

  公开号：US20020137737A1

  公开（公告）日：2002-09-26

  This invention relates to novel lactams having the Formula (I): 1 to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.

  这项发明涉及具有式(I)的新型内内酰胺，以及它们的药物组合物和使用方法。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地说，抑制Aβ-肽的产生，从而防止淀粉样蛋白的神经沉积形成。更具体地说，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，如阿尔茨海默病和唐氏综合征。
• Lactams substituted by cyclic succinates as inhibitors of Abeta protein production
  申请人：Olson E. Richard

  公开号：US20050261274A1

  公开（公告）日：2005-11-24

  This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型内酰胺，其制药组成物和使用方法。这些新化合物抑制淀粉样前体蛋白的处理，更具体地抑制Aβ-肽的产生，从而防止神经元中淀粉样蛋白的沉积形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，如阿尔茨海默病和唐氏综合症。
• Lactams substituted by cyclic succinates as inhibitors of A-beta protein production
  申请人：——

  公开号：US20030119815A1

  公开（公告）日：2003-06-26

  This invention relates to novel lactams having the Formula (I): 1 to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式(I)的新型内酰胺，以及它们的制药组合物和使用方法。这些新化合物抑制淀粉样前体蛋白的处理，更具体地抑制Aβ-肽的产生，从而防止神经元中出现淀粉样蛋白质的沉积。更具体地说，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，如阿尔茨海默病和唐氏综合症。
• LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF ABETTA PROTEIN PRODUCTION
  申请人：Olson E. Richard

  公开号：US20080103128A1

  公开（公告）日：2008-05-01

  This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有式(I)的新型内酰胺，它们的制药组合物和使用方法。这些新型化合物抑制淀粉样前体蛋白的加工，更具体地说，抑制Aβ肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。
• LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
  申请人：Olson Richard E.

  公开号：US20090062256A1

  公开（公告）日：2009-03-05

  This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

  本发明涉及具有公式（I）的新型内酰胺、它们的制药组合物以及它们的使用方法。这些新型化合物抑制淀粉样前体蛋白的处理，更具体地抑制Aβ-肽的产生，从而防止神经沉积物的淀粉样蛋白形成。更具体地，本发明涉及与β-淀粉样蛋白产生相关的神经系统疾病的治疗，例如阿尔茨海默病和唐氏综合症。