3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid methyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid methyl ester
• 英文别名: 3-(6-Methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-ensaeure-methylester；methyl (Z)-3-(6-methoxynaphthalen-2-yl)-2,2-dimethylpent-3-enoate
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: KZKMTHZTVSFKCN-FMQZQXMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid methyl ester 在 甲醇 、 sodium hydroxide 、 1-methoxyethanol 、 溶剂黄146 、 铂 作用下， 生成 美沙雌酸
  参考文献：
  名称：

  Abk�mmlinge alkylierter ?-Naphtyl-valerians�uren. �ber oestrogene Carbons�uren XXVI

  摘要：

  AbstractAusgehend von 6‐Methoxy‐2‐tetralon wurden die beiden Racemate der α, α‐Dimethyl‐β‐(6‐methoxy‐l,2,3,4‐tetrahydro‐2‐naphtyl)‐valeriansäure hergestellt.

  DOI：

  10.1002/hlca.19480310650
• 作为产物：
  描述：

  2-萘甲醚 在 乙醚 、 四氯化锡 、 magnesium 、 苯 作用下， 生成 3-(6-methoxy-[2]naphthyl)-2,2-dimethyl-pent-3-enoic acid methyl ester
  参考文献：
  名称：

  spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis

  摘要：

  Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis, a phenomenon called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature and is suppressed by a single recessive mutant, mcs3-12. Mcs3 acts independently of the Wee1 kinase and Cdc25 phosphatase, two major regulators of Cdc2. We have isolated multicopy suppressors of the cell cycle arrest phenotype of mcs3-12 wee1-50 cdc25-22 cells, but did not identify the mcs3 gene itself. Instead several known mitotic regulators were isolated, including the Cdc25 phosphatase, Wis2 cyclophilin, Cek1 kinase. and an Hsp90 homologue, Swo1. We also isolated clones encoding non-functional, truncated forms of the Wee1 kinase and Dis2 type 1 phosphatase. In addition we identified a multicopy suppressor that encodes a structural homologue of the budding yeast SPO12 gene. We find that overexpression of fission yeast spo12 not only suppresses the phenotype of the mcs3-12 wee1-50 cdc25-22 strain, but also that of a win1-1 wee1-50 cdc25-22 strain at high temperature, indicating that the function of spo12 is not directly related to mcs3. We show that spo12 mRNA is periodically expressed during the fission yeast cell cycle, peaking at the G2/M transition coincidently with cdc15. Deletion of spo12, however, has no overt effect on either the mitotic or meiotic cell cycles, except when the function of the major B type cyclin, Cdc13, is compromised.

  DOI：

  10.1007/s004380000324

文献信息

• spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis
  作者：J. M. Samuel、N. Fournier、V. Simanis、J. B. A. Millar

  DOI：10.1007/s004380000324

  日期：2000.10

  Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis, a phenomenon called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature and is suppressed by a single recessive mutant, mcs3-12. Mcs3 acts independently of the Wee1 kinase and Cdc25 phosphatase, two major regulators of Cdc2. We have isolated multicopy suppressors of the cell cycle arrest phenotype of mcs3-12 wee1-50 cdc25-22 cells, but did not identify the mcs3 gene itself. Instead several known mitotic regulators were isolated, including the Cdc25 phosphatase, Wis2 cyclophilin, Cek1 kinase. and an Hsp90 homologue, Swo1. We also isolated clones encoding non-functional, truncated forms of the Wee1 kinase and Dis2 type 1 phosphatase. In addition we identified a multicopy suppressor that encodes a structural homologue of the budding yeast SPO12 gene. We find that overexpression of fission yeast spo12 not only suppresses the phenotype of the mcs3-12 wee1-50 cdc25-22 strain, but also that of a win1-1 wee1-50 cdc25-22 strain at high temperature, indicating that the function of spo12 is not directly related to mcs3. We show that spo12 mRNA is periodically expressed during the fission yeast cell cycle, peaking at the G2/M transition coincidently with cdc15. Deletion of spo12, however, has no overt effect on either the mitotic or meiotic cell cycles, except when the function of the major B type cyclin, Cdc13, is compromised.
• Abk�mmlinge alkylierter ?-Naphtyl-valerians�uren. �ber oestrogene Carbons�uren XXVI
  作者：P. Wieland、K. Miescher

  DOI：10.1002/hlca.19480310650

  日期：——

  AbstractAusgehend von 6‐Methoxy‐2‐tetralon wurden die beiden Racemate der α, α‐Dimethyl‐β‐(6‐methoxy‐l,2,3,4‐tetrahydro‐2‐naphtyl)‐valeriansäure hergestellt.