2-({1-[(E)-2-phenyl-1-diazenyl]-2-naphthyl}oxy)-1-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-({1-[(E)-2-phenyl-1-diazenyl]-2-naphthyl}oxy)-1-ethanol
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: QALRILASAUUQNV-FMQUCBEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.18
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-({1-[(E)-2-phenyl-1-diazenyl]-2-naphthyl}oxy)-1-ethanol 、 丙炔酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醚 为溶剂， 以75%的产率得到2-({1-[(E)-2-phenyl-1-diazenyl]-2-naphthyl}oxy)ethyl propiolate
  参考文献：
  名称：

  Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms

  摘要：

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10324-6
• 作为产物：
  描述：

  苏丹-1 在 4-甲基苯磺酸吡啶 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-({1-[(E)-2-phenyl-1-diazenyl]-2-naphthyl}oxy)-1-ethanol
  参考文献：
  名称：

  Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms

  摘要：

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10324-6

文献信息

• Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms
  作者：Geoffrey T. Crisp、Michael J. Millan

  DOI：10.1016/s0040-4020(97)10324-6

  日期：1998.1

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.