5'-Acetyl-4-{[(2,4-dimethylphenyl)sulfonyl]amino}-2,2'-bithiophene-5-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 5'-Acetyl-4-{[(2,4-dimethylphenyl)sulfonyl]amino}-2,2'-bithiophene-5-carboxylic acid
• 英文别名: 5-(5-acetylthiophen-2-yl)-3-[(2,4-dimethylphenyl)sulfonylamino]thiophene-2-carboxylic acid
• 化学式: C₁₉H₁₇NO₅S₃
• 分子量: 435.5
• InChiKey: CMHHNHDPPWDNAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  165
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Compounds and methods for the treatment or prevention of Flavivirus infections
  申请人：Chan Chun Kong Laval

  公开号：US20060142347A1

  公开（公告）日：2006-06-29

  The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

  本发明提供了由公式I表示的新化合物：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。
• COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
  申请人：Chan Chun Kong Laval

  公开号：US20110200553A1

  公开（公告）日：2011-08-18

  The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

  本发明提供了新的化合物，其公式表示为I：或其药学上可接受的盐，用于治疗黄病毒科病毒感染。
• Thiophene derivatives as antiviral agents for flavivirus infection
  申请人：Virochem Pharma Inc.

  公开号：EP2206709A2

  公开（公告）日：2010-07-14

  The present invention provides novel compounds represented by formula I or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.

  本发明提供了由式 I 代表的新型化合物或其药学上可接受的盐类，可用于治疗黄病毒科病毒感染。
• THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION
  申请人：Virochem Pharma Inc.

  公开号：EP1401825B1

  公开（公告）日：2009-08-05
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.