1,2-Dioctanoyl-sn-glycero-3-phosphoserine | 128704-86-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-Dioctanoyl-sn-glycero-3-phosphoserine
• 英文别名: (2S)-2-amino-3-[[(2R)-2,3-di(octanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
• CAS: 128704-86-9
• 化学式: C₂₂H₄₂NO₁₀P
• 分子量: 511.5
• InChiKey: TWOCGGYLNFTSJO-MOPGFXCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  34
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  172
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• [EN] FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION<br/>[FR] COMPOSÉS DE TRIAZOLO-PYRIMIDINE FUSIONNÉS AYANT UNE APPLICATION PHARMACEUTIQUE UTILE
  申请人：NANOSYN INC

  公开号：WO2018175906A1

  公开（公告）日：2018-09-27

  A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

  一个化合物和/或其药学上可接受的盐具有以下公式A：这些化合物可以是PIKfyve激酶抑制剂。
• FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND POLYPEPTIDES FOR APPLICATION TO TRANSMEMBRANE DRUG DELIVERY SYSTEMS
  申请人：Children's Hospital Medical Center

  公开号：EP3357490A1

  公开（公告）日：2018-08-08

  The present invention includes pharmaceutical and/or imaging agents and methods for delivering the agent(s) within and/or through the dermal, mucosal and other cellular membranes. The agents can include a fusogenic protein. This technology can be used for applications in which the objective is delivery of active agent within and/or beneath biological membranes and/or across the blood-brain barrier and neuronal membranes.

  本发明包括药物和/或成像制剂以及在皮肤、粘膜和其他细胞膜内和/或通过皮肤、粘膜和其他细胞膜输送制剂的方法。这些制剂可包括致熔蛋白。该技术可用于在生物膜内和/或生物膜下和/或穿过血脑屏障和神经元膜输送活性剂的应用。
• Liposomal formulation of nonglycosidic ceramides and uses thereof
  申请人：LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

  公开号：US10039715B2

  公开（公告）日：2018-08-07

  The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.

  本发明提供了在其双层内含有非糖苷类神经酰胺的脂质体及其组合物。这些脂质体可在体外和体内激活小鼠 iNKT 细胞并诱导树突状细胞（DC）成熟，其功效与相应的可溶性非糖苷神经酰胺相当。此外，还提供了使用本发明脂质体和组合物治疗疾病的方法。
• Fused triazolo-pyrimidine compounds having useful pharmaceutical application
  申请人：NANOSYN, INC.

  公开号：US11066410B2

  公开（公告）日：2021-07-20

  A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

  一种化合物和/或其药学上可接受的盐具有下式 A： 这些化合物可以是 PIKfyve 激酶抑制剂。
• COMPOSITIONS COMPRISING FUSOGENIC PROTEINS OR POLYPEPTIDES DERIVED FROM PROSAPOSIN FOR APPLICATION IN TRANSMEMBRANE DRUG DELIVERY SYSTEMS
  申请人：Children's Hospital Medical Center

  公开号：EP2020988A2

  公开（公告）日：2009-02-11