1,4-bis(4-hydroxyphenylethynyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1,4-bis(4-hydroxyphenylethynyl)benzene
• 英文别名: 4-[2-[4-[2-(4-Hydroxyphenyl)ethynyl]phenyl]ethynyl]phenol
• 化学式: C₂₂H₁₄O₂
• 分子量: 310.352
• InChiKey: KUZARKWVQOZWEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  四乙二醇二对甲苯磺酸酯 、 1,4-bis(4-hydroxyphenylethynyl)benzene 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 以51%的产率得到(((((((((1,4-phenylenebis(ethyne-2,1-diyl))bis(4,1-phenylene))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
  参考文献：
  名称：

  Mimicking multipass transmembrane proteins: synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

  摘要：

  交替疏水性的多嵌段分子1-4，涉及荧光疏水单元，被设计成模拟多跨膜蛋白。在脂质体膜中对1-4进行的荧光光谱分析表明，疏水单元面对面堆叠形成了折叠结构以及分子间组装体。

  DOI：

  10.1039/c0cc02420a
• 作为产物：
  描述：

  4-碘乙酰基苯酚 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 反应 8.0h， 生成 1,4-bis(4-hydroxyphenylethynyl)benzene
  参考文献：
  名称：

  蛍光色素及びこれを用いた標識生体物質

  摘要：

  目的] 提供能够获得在溶液、膜和点阵条件下均表现出优异荧光强度的标记生物材料的荧光染料和标记生物材料。解答】由以下通式（I）或（II）代表的荧光染料和标记生物物质。） TIFF 2022131357000041.tif 12 161 式中，M 表示 t 价连接基团，其中 t 为 3 或 3 以上的整数。 L 表示二价连接基团，由至少两个-C≡C-、芳烯基和杂芳基组合而成。 X 表示醚键、硫醚键、亚烷基、酰胺键、酯键或氨基键。 R 表示荧光粉部分。无。

  公开号：

  JP2022131357A

文献信息

• 신규한 디히드록시폴리아릴아세틸렌, 고경도 폴리카보네이트 공중합체 및 그 제조방법
  申请人：LG CHEM, LTD. 주식회사 엘지화학(120010134563) Corp. No ▼ 110111-2207995BRN ▼107-81-98139

  公开号：KR20150003653A

  公开（公告）日：2015-01-09

  본 발명은 신규한 디히드록시폴리아릴아세테이트에 관한 것으로, 보다 상세하게는 하기 화학식 1 (R~R, R’~R’는 독립적으로 H, OH, CH, 탄소수 2 내지 6의 알케닐기, 탄소수 6 내지 12의 시클로알킬렌기, 탄소수 6 내지 12의 아릴렌기로부터 선택되고, n은 1 내지 10의 정수이다)로 표시되는 화합물인 것을 특징으로 하는 신규한 디히드록시폴리아릴아세테이트, 이를 이용한 폴리카보네이트 공중합체의 제조 방법 및 고경도 폴리카보네이트 공중합체에 관한 것이다. 본 발명에 따르면, 충격보강제, 개질제 또는 공단량체로 사용 가능한 신규한 디히드록시폴리아릴아세테이트 유도체를 제공하고, 동시에 내열성이 우수한 고경도 폴리카보네이트 공중합체를 제공하는 효과가 있다.

  本发明涉及一种新的双羟基聚芳酯醋酸酯，更详细地表示为化学式1（其中R〜R，R'〜R'独立地选择自H，OH，CH，2至6个碳原子的烷基，6至12个碳原子的环烷烃基，6至12个碳原子的芳基烃基，n为1至10的整数），以及使用它制备聚碳酸酯共聚物的方法和高抗冲聚碳酸酯共聚物。根据本发明，提供了一种新的双羟基聚芳酯醋酸酯衍生物，可用作冲击增强剂，改性剂或单体，同时提供了具有优异耐热性的高抗冲聚碳酸酯共聚物。
• A tight 1:1 complex between an allosteric receptor and an organic effector with hydrogen and coordination bonds
  作者：Yoshito Sasaki、Shuichi Suzuki、Keiji Okada、Masatoshi Kozaki

  DOI：10.1016/j.tetlet.2016.07.088

  日期：2016.9

  effector 2, possessing a uracil and two pyridine units, formed a tight 1:1 supramolecular complex with 1. The binding constant of ZnDEDPP in 1 with 4-phenylpyridine was 4.2 times larger than that of ZnDEDPP in 1·2, indicating that compound 2 functions as an allosteric effector for the complexation of 1 and 4-phenylpyridine.

  通过在苯环的位置1引入线性共轭链以及在位置2和6引入两个侧链来构建变构系统1。共轭链由延伸至二亚氨基吡啶末端的二乙炔基二苯基卟啉锌中心（ZnDEDPP）组成。侧臂具有通过柔性乙二氧基连接的四苯基卟啉锌末端（ZnTPP）。具有尿嘧啶和两个吡啶单元的有机效应子2与1形成紧密的1：1超分子复合物。ZnDEDPP在1中与4-苯基吡啶的结合常数是ZnDEDPP在1 · 2中的结合常数的4.2倍，表明化合物2作为1和4-苯基吡啶的络合的变构效应子。
• Supramolecular Mechanosensitive Potassium Channel Formed by Fluorinated Amphiphilic Cyclophane
  作者：Kohei Sato、Ryo Sasaki、Ryoto Matsuda、Mayuko Nakagawa、Toru Ekimoto、Tsutomu Yamane、Mitsunori Ikeguchi、Kazuhito V. Tabata、Hiroyuki Noji、Kazushi Kinbara

  DOI：10.1021/jacs.2c04118

  日期：2022.7.6

  potassium channels found in nature, we developed a fluorinated amphiphilic cyclophane composed of fluorinated rigid aromatic units connected via flexible hydrophilic octa(ethylene glycol) chains. Microscopic and emission spectroscopic studies revealed that the cyclophane could be incorporated into the hydrophobic layer of the lipid bilayer membranes and self-assembled to form a supramolecular transmembrane

  受自然界中发现的机械敏感钾通道的启发，我们开发了一种氟化两亲环烷，该环烷由氟化刚性芳族单元通过柔性亲水八（乙二醇）链连接而成。显微镜和发射光谱研究表明，环烷可以掺入脂质双层膜的疏水层并自组装形成超分子跨膜离子通道。使用含环烷的平面脂质双层膜的电流记录测量成功地证明了有效的跨膜离子传输。我们还证明了离子传输特性对施加在膜上的机械力很敏感。此外，使用 pH 敏感荧光染料进行的离子传输测定表明，超分子通道具有钾离子选择性。我们还进行了全原子混合量子力学/分子力学模拟，以评估原子分辨率下的通道结构和选择性钾离子传输的机制。这项研究展示了合成机械敏感钾通道的第一个例子，这将为传感和操纵生物重要过程以及工业中关键材料的纯化打开一扇新的大门。
• The Interplay of Bent-Shape, Lateral Dipole and Chirality in Thiophene Based Di-, Tri-, and Tetracatenar Liquid Crystals
  作者：S. Holger Eichhorn、Alexander J. Paraskos、Keiki Kishikawa、Timothy M. Swager

  DOI：10.1021/ja0268027

  日期：2002.10.1

  A range of mesogenic molecules varying in both bend angle and strength of lateral dipole were synthesized, and their phase behavior was characterized by polarizing microscopy, thermal analysis, X-ray diffraction, and electrooptical measurements. We find the general destabilization of the liquid crystallinity caused by strong lateral dipolar groups and the bent molecular shape are off-set in mesomorphic tetracatenars, which display stable nematic, smectic, columnar, and cubic mesophases. The broad mesomorphism of the tetracatenars containing lateral dipoles and their incompatibility with chiral induction are explained by considering that loosely correlated dimers exist within the mesophases. Chiral mesophases of derivatives with strong lateral dipoles were achieved by attaching fewer or different side chains to each end of the mesogen.
• Phenolic Bis-styrylbenzenes as β-Amyloid Binding Ligands and Free Radical Scavengers
  作者：Daniel P. Flaherty、Tomomi Kiyota、Yuxiang Dong、Tsuneya Ikezu、Jonathan L. Vennerstrom

  DOI：10.1021/jm1006929

  日期：2010.11.25

  Starting from bisphenolic bis-styrylbenzene DF-9 (4), P-amyloid (A beta) binding affinity and specificity for phenolic bis-styrylbenzenes, monostyrylbenzenes, and alkyne controls were determined by fluorescence titration with beta-amyloid peptide A beta(1-40) and a fluorescence assay using APP/PSI transgenic mouse brain sections. Bis-styrylbenzene SA R is derived largely from work on symmetrical compounds. This study is the first to describe A beta binding data for bis-styrylbenzenes unsymmetrical in the outer rings. With one exception, binding affinity and specificity were decreased by adding and/or changing the substitution pattern of phenol functional groups, changing the orientation about the central phenyl ring, replacing the alkene with alkyne bonds, or eliminating the central phenyl ring. The only compound with an A beta binding affinity and specificity comparable to 4 was its 3-hydroxy regioisomer 8. Like 4, 8 crossed the blood brain barrier and bound to A beta plaques in vivo. By use of a DPPH assay, phenol functional groups with papa orientations seem to be a necessary. but insufficient, criterion for good free radical scavenging properties in these compounds.