双(二甲基马来酰)肼 | 6903-84-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 双(二甲基马来酰)肼
• 中文别名: 双（二甲基马来酰）肼
• 英文名称: [1,1'-bipyrrole]-2,2',5,5'-tetraone
• 英文别名: [1,1']bipyrrolyl-2,5,2',5'-tetraone；[1,1']Bipyrrolyl-2,5,2',5'-tetraon；N,N'-Bis-(maleinsaeure-imid)；N,N'-Bis-maleinsaeureimid；N,N'-Bismaleinimid；1-(2,5-dioxopyrrol-1-yl)pyrrole-2,5-dione
• CAS: 6903-84-0
• 化学式: C₈H₄N₂O₄
• 分子量: 192.131
• InChiKey: PCNTZEWNQWMZCG-UHFFFAOYSA-N

物化性质

• 熔点：
  259-260 °C (decomp)(Solv: 1,4-dioxane (123-91-1))
• 沸点：
  354.9±25.0 °C(Predicted)
• 密度：
  1.816±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  双(二甲基马来酰)肼 、 1,4-二苯基-1,3丁二烯 以 1,4-二氧六环 为溶剂， 生成 2-(2,5-dioxopyrrol-1-yl)-4,7-diphenyl-3a,4,7,7a-tetrahydroisoindole-1,3-dione
  参考文献：
  名称：

  Adigezalov, N. R.; Kiselev, V. D.; Konovalov, A. I., Journal of Organic Chemistry USSR (English Translation), 1989, vol. 25, # 3.1, p. 486 - 490

  摘要：

  DOI：
• 作为产物：
  描述：

  Bis(1,4-endoxocyclohex-5-en-2,3-dicarboximid) 生成 双(二甲基马来酰)肼
  参考文献：
  名称：

  ADIGEZALOV, N. R.;AXMEDOV, I. M.

  摘要：

  DOI：

文献信息

• DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP1120414A1

  公开（公告）日：2001-08-01

  The present invention relates to a disubstituted maleimide compound of the formula [I] wherein R1 is hydrogen or alkyl, R2 is aryl, cycloalkyl or heterocyclic group, R3, R5, R6, R7 and R8 are hydrogen, halogen, hydroxyl group, amino, alkyl or alkoxy, and R4 is W or R4 and R3, or R4 and R5 jointly form a ring having a substituent W on the ring wherein W is - (CH2)l- (Y)m- (CH2)n-Z, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing this compound, and a protein kinase C (PKC) β inhibitor. The compounds of the present invention selectively inhibit PKCβ, and can be safe and effective pharmaceutical or prophylactic agents against the diseases caused by PKC including diabetic complications.

  本发明涉及一种二取代马来酰亚胺化合物，其化学式为[I]，其中R1为氢或烷基，R2为芳基、环烷基或杂环基，R3、R5、R6、R7和R8为氢、卤素、羟基、氨基、烷基或烷氧基，R4为W或R4和R3，或R4和R5共同形成具有环上取代基W的环，其中W为-(CH2)l-(Y)m-( )n-Z，或其药学上可接受的盐，含有该化合物的药物组合物，以及蛋白激酶C（PKC）β抑制剂。本发明的化合物选择性地抑制PKCβ，并可作为安全有效的药物或预防剂用于对抗由PKC引起的疾病，包括糖尿病并发症。
• Three-Component Synthesis of Quinolines Based on Radical Cascade Visible-Light Photoredox Catalysis
  作者：Jun-Ho Choi、Cheol-Min Park

  DOI：10.1002/adsc.201800734

  日期：2018.9.17

  Synthesis of highly substituted quinolines has been developed based on three‐component radical cascade based on visible‐light photoredox catalysis. This tandem coupling reaction has been coordinated to proceed with high chemoselectivity based on the differential electronic properties of coupling partners. Subjection of electron‐rich β‐aminoacrylates with electron‐deficient halides and alkenes to the

  基于可见光光氧化还原催化的三组分自由基级联反应，已经开发了高度取代的喹啉的合成方法。该串联偶联反应已根据偶联配偶体的不同电子性质进行协调，以高化学选择性进行。将富电子的β-氨基丙烯酸酯与缺电子的卤化物和烯烃置于最佳条件下，会导致原位氧化四氢喹啉后，喹啉以高收率形成。详细的机理研究揭示了意外的反应途径。
• Imide-crosslinked ethylenic polymer resin foams and method of making
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0001666A2

  公开（公告）日：1979-05-02

  Resin foam products which are infusible and insoluble in usual solvents and resist ignition and burning in air are prepared from unsaturated imides such as 4,4'-methylenedianiline- bis-maleimide, unsaturated amic acids such as bis-maleamic acid and mixtures of unsaturated anhydrides such as maleic anhydride and poly(primary amines). The resin foams are made by heating to resin-forming- foaming temperature a reaction mixture containing such starting material, surfactant and blowing agent.

  不饱和酰亚胺（如 4,4'-亚甲基二苯胺-双马来酰亚胺）、不饱和胺基酸（如双马来酰亚胺酸）以及不饱和酸酐（如马来酸酐和聚（伯胺））的混合物可制备可浸润、不溶于普通溶剂且不易在空气中点燃和燃烧的树脂泡沫产品。将含有此类起始材料、表面活性剂和发泡剂的反应混合物加热至树脂发泡温度，即可制成树脂泡沫。
• Thermosetting resin composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0178546A2

  公开（公告）日：1986-04-23

  A thermosetting resin composition comprising an N,N'- bismaleimide compound and an allylated phenol novolak resin having partially or wholly allyl-etherified phenolic hydroxyl groups and substantially no nucleous-substituted allyl group.

  一种热固性树脂组合物，包含一种 N,N'-双马来酰亚胺化合物和一种烯丙基化苯酚酚醛树脂，后者具有部分或全部烯丙基醚化的酚羟基和基本上没有核取代的烯丙基。
• Thermosetting resin composition and a composite material comprising the cured product of the resin composition as its matrix
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0225174A2

  公开（公告）日：1987-06-10

  A thermosetting resin composition comprises a polymaleimide compound having two or more maleimide groups in one molecule, a phenol novolac resin of which phenolic hydroxyl groups are epoxidized and allyl-etherified and, as an optional ingredient, a curing agent. Alternatively, the resin composition comprises a polymaleimide compound having two or more maleimide groups in one molecule, a phenol novolac resin of which phenolic hydroxyl grups are allyl-etherified and an epoxy resin. There are also provided heat resistant fibre-reinforced materials comprising, as matrix phase, the cured products of these thermosetting compounds.

  一种热固性树脂组合物包括一种在一个分子中含有两个或两个以上马来酰亚胺基团的聚马来酰亚胺化合物、一种酚醛树脂（其中的酚羟基被环氧化和烯丙基醚化），以及作为一种可选成分的固化剂。 或者，该树脂组合物包括一种在一个分子中含有两个或两个以上马来酰亚胺基团的聚马来酰亚胺化合物、一种酚醛树脂（其中的酚羟基被烯丙基醚化）和一种环氧树脂。 还提供了耐热纤维增强材料，其基体相包括这些热固性化合物的固化产物。