1-[1-(5-Methoxy-2,2-dimethyl-4a,8a-dihydrochromen-6-yl)ethyl]imidazo[4,5-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-[1-(5-Methoxy-2,2-dimethyl-4a,8a-dihydrochromen-6-yl)ethyl]imidazo[4,5-b]pyridine
• 化学式: C₂₀H₂₃N₃O₂
• 分子量: 337.4
• InChiKey: SQDLCOYVXRIAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Hif-1 inhibitors
  申请人：Van Meir G. Erwin

  公开号：US20070099952A1

  公开（公告）日：2007-05-03

  HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of hypoxia-related pathologies are provided.
• HIF-1 Inhibitors
  申请人：Van Meir Erwin G.

  公开号：US20100087478A1

  公开（公告）日：2010-04-08

  HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of hypoxia-related pathologies are provided.
• US7652033B2
  申请人：——

  公开号：US7652033B2

  公开（公告）日：2010-01-26