2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-3,4,8,9-tetrahydropyrano[2,3-e]isoindol-7-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-3,4,8,9-tetrahydropyrano[2,3-e]isoindol-7-one
• 化学式: C₂₃H₃₁NO₄
• 分子量: 385.5
• InChiKey: XGUHYRYUXUVLOK-OQLLNIDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer
  申请人：Hasumi Keiji

  公开号：US20090216028A1

  公开（公告）日：2009-08-27

  The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  本发明提供了一种由以下化学式（II）和（III）所代表的三倍萜酚化合物，具有增强溶栓活性，以及一种高效制备该三倍萜酚化合物的方法。在化学式（II）和（III）中，R1代表芳香基团，其作为取代基或取代基的一部分至少包括羧基、羟基、磺酸基和二级氨基组成的群中的一种，或者是包含二级氨基并可能包含氮的芳香基团；在通式（III）中，R4代表由通式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别为—H或—OH或形成单键：（III-1）其中，R5代表可能存在或不存在的羟基；n代表0或1的整数。
• TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER
  申请人：HASUMI Keiji

  公开号：US20120100579A1

  公开（公告）日：2012-04-26

  A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  以下为一种由式子（II）和（III）所代表的三倍半萜酚类化合物，具有促进溶血性的活性，以及一种高效的制备该三倍半萜酚类化合物的方法。在式子（II）和（III）中，R1代表一种芳香基团，其作为一个取代基或部分取代基，至少包含羧基、羟基、磺酸基和次级氨基中的一种，或者是包含次级氨基且可能包含氮的芳香基团；在一般式（III）中，R4代表由一般式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别代表—H或—OH，或者一起形成一个单键：（III-1）其中R5代表可能存在或不存在的羟基；n代表0或1的整数。
• Drug and Method of Treating or Preventing Renal Disease Using Drug
  申请人：Showa University

  公开号：US20210000794A1

  公开（公告）日：2021-01-07

  A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.
• DRUG FOR TREATMENT OR PREVENTION OF BLOOD CEREBRAL HEMORRHAGE, AND METHOD FOR TREATING OR PREVENTING CEREBRAL HEMORRHAGE USING THE DRUG
  申请人：TMS CO., LTD.

  公开号：US20210322381A1

  公开（公告）日：2021-10-21

  A drug used for treating or preventing cerebral hemorrhage, the drug including, as an active ingredient, a compound represented by the following Formula (I) or a pharmaceutically acceptable salt, ester, or solvate thereof:
• DRUG AND METHOD FOR TREATING OR PREVENTING COMPLICATIONS FROM DIABETES, USING SAID DRUG
  申请人：TMS Co., Ltd.

  公开号：US20220218664A1

  公开（公告）日：2022-07-14

  A drug containing a compound represented by formula (I) as an active ingredient, used for complications from diabetes.