[2,6-di(propan-2-yl)phenyl] N-(9H-fluorene-9-carbonyl)sulfamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: [2,6-di(propan-2-yl)phenyl] N-(9H-fluorene-9-carbonyl)sulfamate
• 化学式: C₂₆H₂₇NO₄S
• 分子量: 449.6
• InChiKey: CMAJRQLGKHHWEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods of treating nuclear factor-kappa B mediated diseases and disorders
  申请人：——

  公开号：US20020183384A1

  公开（公告）日：2002-12-05

  The present invention provides a method of treating a disease or a disorder responsive to inhibition of nuclear factor-&kgr;B transcription factors comprising administering to a patient in need thereof a sulfonylaminocarbonyl derivative, or a pharmaceutically acceptable salt thereof. The methods of the present invention are useful for treating, for example, rheumatoid arthritis, osteoarthritis, an autoimmune disease, psoriasis, asthma, a cardiovascular disease, an acute coronary syndrome, congestive heart failure, Alzheimer's disease, multiple sclerosis, cancer, type 2 diabetes, metabolic syndrome X, or inflammatory bowel disease.

  本发明提供了一种治疗对核因子κB转录因子抑制有反应的疾病或障碍的方法，包括向需要该方法的患者施用磺酰氨基甲酰衍生物或其药学上可接受的盐。本发明的方法可用于治疗例如风湿性关节炎、骨关节炎、自身免疫疾病、银屑病、哮喘、心血管疾病、急性冠状动脉综合症、充血性心力衰竭、阿尔茨海默病、多发性硬化症、癌症、2型糖尿病、代谢综合征X或炎症性肠病。
• Sulfonylaminocarbonyl derivatives for the treatment of nuclear factor-kappa B mediated diseases and disorders
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1236468A1

  公开（公告）日：2002-09-04

  The present invention provides a method of treating a disease or a disorder responsive to inhibition of nuclear factor-κB transcription factors comprising administering to a patient in need thereof a sulfonylaminocarbonyl derivative, or a pharmaceutically acceptable salt thereof. The methods of the present invention are useful for treating, for example, rheumatoid arthritis, osteoarthritis, an autoimmune disease, psoriasis, asthma, a cardiovascular disease, an acute coronary syndrome, congestive heart failure, Alzheimer's disease, multiple sclerosis, cancer, type II diabetes, metabolic syndrome X, or inflammatory bowel disease.

  本发明提供了一种治疗对抑制核因子-κB转录因子有反应的疾病或失调的方法，包括向有需要的患者施用磺胺羰基衍生物或其药学上可接受的盐。本发明的方法可用于治疗例如类风湿性关节炎、骨关节炎、自身免疫性疾病、银屑病、哮喘、心血管疾病、急性冠状动脉综合征、充血性心力衰竭、阿尔茨海默病、多发性硬化症、癌症、II型糖尿病、代谢综合征X或炎症性肠病。