2-[2,2-Difluoro-3,3,3-tris(methylsulfanyl)propyl]isoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[2,2-Difluoro-3,3,3-tris(methylsulfanyl)propyl]isoindole-1,3-dione
• 化学式: C₁₄H₁₅F₂NO₂S₃
• 分子量: 363.5
• InChiKey: YHMSHGNOHGYHRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• METHODS FOR PREPARING PERFLUORINATED [18 F]-RADIOLABELLED NITROIMIDAZOLE DERIVATIVES FOR CELLULAR HYPOXIA DETECTION
  申请人：UNIVERSITE CATHOLIQUE DE LOUVAIN

  公开号：EP1202945B1

  公开（公告）日：2005-08-17
• [EN] METHODS FOR PREPARING PERFLUORINATED [<18>F]-RADIOLABELLED NITROIMIDAZOLE DERIVATIVES FOR CELLULAR HYPOXIA DETECTION<br/>[FR] PROCEDES DE PREPARATION DE DERIVES DE NITRO-IMIDAZOLE PERFLUORES RADIOMARQUES AU [<18>F] SERVANT A DETECTER L'HYPOXIE CELLULAIRE
  申请人：UNIV LOUVAIN

  公开号：WO2001012575A1

  公开（公告）日：2001-02-22

  The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as indicators for tissue hypoxia. More particularly, the present invention relates to the synthesis and the use of [18F] labelled perfluorinated nitroimidazole compounds having an incorporation of [18F] atoms characterized by a specific radioactivity of the compound comprised between 1 and 30 Ci/mmol, preferably between 1 and 20 Ci/mmol, preferably 1 and 10 Ci/mmol. More particularly to [18F] labelled EF3 or [18F] labelled EF5. The present invention also relates to a method for the detection of tissue hypoxia in a patient comprising introducing an [18F] labelled nitroimidazole compound into said patient, imaging tissue hypoxia in said patient, and, quantifying tissue hypoxia in said patient.