2-allyloxyethyl phosphorylcholine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-allyloxyethyl phosphorylcholine
• 英文别名: 2-Prop-2-enoxyethyl 2-(trimethylazaniumyl)ethyl phosphate
• 化学式: C₁₀H₂₂NO₅P
• 分子量: 267.262
• InChiKey: UZCAFQIRXZUZHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  三乙氧基硅烷 、 2-allyloxyethyl phosphorylcholine 在 platinum on activated charcoal 作用下， 以 乙醇 为溶剂， 反应 7.0h， 以30%的产率得到2-(3-triethoxysilylpropyloxy)ethylphosphorylcholine
  参考文献：
  名称：

  シリル基含有ホスホリルコリン化合物及びその製造方法、並びに、重縮合体及び表面改質剤

  摘要：

  提供一种含有硅基的磷酰胆碱化合物，其由下式（1）表示。在式（1）中，R1和R2表示碳数为1或2的烷氧基。R3表示甲基和碳数为1或2的烷氧基中的任意一个。R4表示含有卡巴酰胺骨架。【选择图】无

  公开号：

  JP2015110534A
• 作为产物：
  描述：

  烯丙基羟乙基醚 、 甲苯磺酸胆碱 在 吡啶 、 三氯氧磷 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 32.0h， 以65%的产率得到2-allyloxyethyl phosphorylcholine
  参考文献：
  名称：

  JP5751578

  摘要：

  公开号：

文献信息

• POLYSACCHARIDE-BASED GRAFT COPOLYMER AND COMPOSITION COMPRISING SAME FOR PERSONAL CARE
  申请人：Kci Limited

  公开号：EP2660252A2

  公开（公告）日：2013-11-06

  The present invention relates to a graft copolymer including a polysaccharide as a main chain and a phosphorylcholine analogous group-containing monomer as a side chain, and a composition for skin and hair care including the copolymer as an active ingredient. The graft copolymer according to the present invention exhibits more improved moisturizing capacity and better biocompatibility than the existing polysaccharide-based graft copolymer by introducing a phosphorylcholine analogous group-containing compound, and accordingly, the composition for hair and skin care including the same also has improved moisturizing capacity, protection capacity of damaged hair, skin affinity, a skin barrier function, and the like.

  本发明涉及一种包括作为主链的多糖和作为侧链的含磷酸胆碱类似基团单体的接枝共聚物，以及一种包括该共聚物作为活性成分的护肤和护发组合物。根据本发明的接枝共聚物通过引入含磷酸胆碱类似基团的化合物，比现有的多糖基接枝共聚物具有更高的保湿能力和更好的生物相容性，相应地，包括本发明的接枝共聚物的护发护肤组合物也具有更高的保湿能力、对受损头发的保护能力、皮肤亲和性、皮肤屏障功能等。
• SURFACE-MODIFIED ULTRAVIOLET BLOCKING POWDER AND ULTRAVIOLET BLOCKING COMPOSITION INCLUDING SAME
  申请人：KCI Co.,ltd

  公开号：EP2772247A1

  公开（公告）日：2014-09-03

  The present invention relates to a surface-modified ultraviolet blocking powder obtained by reacting an ultraviolet blocking powder including a chloroacetyl group, a phospholipid monomer including an unsaturated bonding, and a catalyst inducing the reaction of the chloroacetyl group and the unsaturated bonding. According to the surface-modified ultraviolet blocking powder of the present invention, the surface may be modified using an effective method, and through chemical bonding (covalent bonding) and as a result of surface modification, the stability of the powder is high. In addition, since the surface modification is performed by using a biocompatible component, the ultraviolet blocking composition including the surface-modified ultraviolet blocking powder may provide ultraviolet blocking properties and biocompatibility at the same time.

  本发明涉及一种表面改性紫外线阻挡粉末，该粉末由包括氯乙酰基的紫外线阻挡粉末、包括不饱和键的磷脂单体和诱导氯乙酰基与不饱和键反应的催化剂反应而得。根据本发明的表面改性紫外线阻隔粉末，可以使用有效的方法对表面进行改性，通过化学键（共价键）和表面改性的结果，粉末的稳定性很高。此外，由于表面改性是通过使用生物相容性成分进行的，因此包括表面改性紫外线阻挡粉末在内的紫外线阻挡组合物可以同时提供紫外线阻挡特性和生物相容性。
• Hydrophilic copolymer with one thiol-containing terminal group
  申请人：Novartis AG

  公开号：US10287370B2

  公开（公告）日：2019-05-14

  The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

  本发明涉及一类亲水聚合物，每种聚合物都包含一个唯一的含硫醇末端基团。这种亲水聚合物在加热时对含氮杂环丁烷聚合物的氮杂环丁烷基团具有高活性，特别适用于生产水溶性高支链亲水聚合物材料，可用于生产水梯度隐形眼镜。
• Hydrogel contact lenses with lubricious coating thereon
  申请人：Novartis AG

  公开号：US10449739B2

  公开（公告）日：2019-10-22

  The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

  本发明一般与软性隐形眼镜有关，软性隐形眼镜包括非硅酮水凝胶镜片主体和其上的水凝胶涂层。非硅酮水凝胶镜片本体由不含硅酮的水凝胶材料组成，该水凝胶材料由至少一种含羟基乙烯基单体的至少 50%（摩尔）重复单元组成。水凝胶涂层包括具有第一反应性官能团的第一聚合物材料和由具有第二反应性官能团的第二聚合物材料衍生的水凝胶层，水凝胶层通过一个第一反应性官能团和一个第二反应性官能团之间各自形成的连接共价连接到锚定层上。软性隐形眼镜的表面润滑性优于非硅水凝胶镜片本体的润滑性，在 7 次手动摩擦后，摩擦等级约为 2 或更低，含水量约为 10%至约 85%（按重量计），在室温下完全水合时的弹性模量约为 0.2 兆帕至约 1.5 兆帕。
• Colored hydrogel contact lenses with lubricious coating thereon
  申请人：Novartis AG

  公开号：US10589479B2

  公开（公告）日：2020-03-17

  The invention is generally related to colored contact lenses which comprise a hydrogel lens body having an opaque color image therein and/or thereon and a durable lubricious coating thereon. The coating comprises an anchoring layer of a polyanionic polymer having carboxyl groups and a hydrogel layer which is derived from a hydrophilic polymeric material having azetidinium groups and is covalently attached onto the anchoring layer of the polyanionic polymer through linkages each formed between one carboxyl group and one azetidinium groups. The colored contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and a friction rating of about 2 or lower after 7 cycles of manual rubbing.

  本发明一般与彩色隐形眼镜有关，彩色隐形眼镜包括一个水凝胶镜片体，镜片体内和/或镜片上有一个不透明的彩色图像，镜片上有一层耐久的润滑涂层。涂层包括一个具有羧基的聚阴离子聚合物锚定层和一个水凝胶层，水凝胶层由具有氮杂环丁烷基团的亲水性聚合物材料制成，并通过一个羧基和一个氮杂环丁烷基团之间的连接共价连接到聚阴离子聚合物锚定层上。彩色隐形眼镜的表面润滑性优于非硅水凝胶镜片本体的润滑性，在 7 次手动摩擦后，摩擦等级约为 2 或更低。