tert-butyl 3-cyano-2-(2-ethylbutanoylamino)-5,6-dihydro-4H-thieno[2,3-b]pyridine-7-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: tert-butyl 3-cyano-2-(2-ethylbutanoylamino)-5,6-dihydro-4H-thieno[2,3-b]pyridine-7-carboxylate
• 化学式: C₁₉H₂₇N₃O₃S
• 分子量: 377.5
• InChiKey: RKOYAYHYUWBECA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Substituted bicyclic thiophene derivatives, compositions containing such compounds and methods of use
  申请人：Duffy Joseph

  公开号：US20050239865A1

  公开（公告）日：2005-10-27

  The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.

  本发明涉及取代噻吩衍生物，以及含有这些化合物的组合物和治疗方法。本发明中的化合物是胰高血糖素拮抗剂。这些化合物可以阻断胰高血糖素在其受体上的作用，从而降低血浆葡萄糖水平，提供糖尿病的治疗。
• SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Merck & Co., Inc.

  公开号：EP1549655A2

  公开（公告）日：2005-07-06
• EP1549655A4
  申请人：——

  公开号：EP1549655A4

  公开（公告）日：2006-05-31
• US7273876B2
  申请人：——

  公开号：US7273876B2

  公开（公告）日：2007-09-25
• [EN] SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE<br/>[FR] DERIVES DE THIOPHENE BICYCLIQUES SUBSTITUES, COMPOSTIONS CONTENANT LESDITS COMPOSES ET METHODES D'UTILISATION
  申请人：MERCK & CO INC

  公开号：WO2004024065A2

  公开（公告）日：2004-03-25

  The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.