5-(1-benzothiophen-3-yl)-N-(4-methoxyphenyl)-1H-pyrazol-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-(1-benzothiophen-3-yl)-N-(4-methoxyphenyl)-1H-pyrazol-3-amine
• 化学式: C₁₈H₁₅N₃OS
• 分子量: 321.4
• InChiKey: ZVHORMHWVMFFKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  78.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compounds, pharmaceutical compositions, and methods for inhibiting protein kinases
  申请人：——

  公开号：US20020006952A1

  公开（公告）日：2002-01-17

  Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

  氨基吡唑化合物，可调节和/或抑制蛋白激酶的活性。这些化合物和含有它们的药物组成物能够介导和/或抑制周期依赖性激酶的活性，从而调节和/或抑制不必要的细胞增殖。该发明还涉及含有这种化合物的药物组成物的治疗或预防用途，以及通过给予有效量的这种化合物的方法来治疗癌症以及与不必要的血管生成和/或细胞增殖相关的其他疾病状态，如糖尿病视网膜病变、新生血管性青光眼、类风湿性关节炎和银屑病。
• US6462069B2
  申请人：——

  公开号：US6462069B2

  公开（公告）日：2002-10-08